ArticleThe Journal of physiology2016
Rigid and remodelled: cerebrovascular structure and function after experimental high-thoracic spinal cord transection.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Peripheral Vascular Dysfunction Following Spinal Cord Injury: A Systematic Review and Meta-Analysis.Topics in spinal cord injury rehabilitation · 2025Pooled it
- Sleep-disordered breathing is associated with brain vascular reactivity in spinal cord injury.Neurology · 2019Pooled it
- Cold pressor test in spinal cord injury-revisited.Spinal cord · 2018Pooled it
- Effects of 30-Day Midodrine Administration, Compared to Placebo, on Blood Pressure, Cerebral Blood Flow Velocity, and Cognitive Performance in Persons with SCI.Topics in spinal cord injury rehabilitation · 2024Trial
- Dysreflexic dilemma: do we need a revised definition for autonomic dysreflexia?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Vascular-Cognitive Impairment following High-Thoracic Spinal Cord Injury Is Associated with Structural and Functional Maladaptations in Cerebrovasculature.Journal of neurotrauma · 2020Article
- Sex differences in the structure and function of rat middle cerebral arteries.American journal of physiology. Heart and circulatory physiology · 2020Article
- Duration and magnitude of bidirectional fluctuation in blood pressure: the link between cerebrovascular dysfunction and cognitive impairment following spinal cord injury.Journal of neurobiology and physiology · 2020Article
- Paradoxical effects of continuous high dose gabapentin treatment on autonomic dysreflexia after complete spinal cord injury.Experimental neurology · 2020Article
- Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats.Experimental and therapeutic medicine · 2019Article
- Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury.Spinal cord · 2019Article
- The Blood Pressure Pendulum following Spinal Cord Injury: Implications for Vascular Cognitive Impairment.International journal of molecular sciences · 2019Review
- The sympathetic role of glutamatergic paraventricular nucleus neurons in blood pressure regulation.The Journal of physiology · 2019Article
- Time-dependent changes in paw carrageenan-induced inflammation above and below the level of low thoracic spinal cord injury in rats.Spinal cord · 2018Article
- Anatomical and Functional Changes to the Colonic Neuromuscular Compartment after Experimental Spinal Cord Injury.Journal of neurotrauma · 2018Article
- Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury.American journal of physiology. Heart and circulatory physiology · 2018Article
- Transient Hypertension after Spinal Cord Injury Leads to Cerebrovascular Endothelial Dysfunction and Fibrosis.Journal of neurotrauma · 2018Article
- Autonomic dysreflexia after spinal cord injury: Systemic pathophysiology and methods of management.Autonomic neuroscience : basic & clinical · 2018Review
- Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats.Journal of the American Heart Association · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
High-thoracic or cervical spinal cord injury (SCI) is associated with several critical clinical conditions related to impaired cerebrovascular health, including: 300-400% increased risk of stroke, cognitive decline and diminished cerebral blood flow regulation. The purpose of this study was to examine the influence of high-thoracic (T3 spinal segment) SCI on cerebrovascular structure and function, as well as molecular markers of profibrosis. Seven weeks after complete T3 spinal cord transection (T3-SCI, n = 15) or sham injury (Sham, n = 10), rats were sacrificed for either middle cerebral artery (MCA) structure and function assessments via ex vivo pressure myography, or immunohistochemical analyses. Myogenic tone was unchanged, but over a range of transmural pressures, inward remodelling occurred after T3-SCI with a 40% reduction in distensibility (both P < 0.05), and a 33% reduction in vasoconstrictive reactivity to 5-HT trending toward significance (P = 0.09). After T3-SCI, the MCA had more collagen I (42%), collagen III (24%), transforming growth factor β (47%) and angiotensin II receptor type 2 (132%), 27% less elastin as well as concurrent increased wall thickness and reduced lumen diameter (all P < 0.05). Sympathetic innervation (tyrosine hydroxylase-positive axon density) and endothelium-dependent dilatation (carbachol) of the MCA were not different between groups. This study demonstrates profibrosis and hypertrophic inward remodelling within the largest cerebral artery after high-thoracic SCI, leading to increased stiffness and possibly impaired reactivity. These deleterious adaptations would substantially undermine the capacity for regulation of cerebral blood flow and probably underlie several cerebrovascular clinical conditions in the SCI population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.