Evidence map›Paper›PMID 26634403›Full record

ArticleInternational journal of immunopathology and pharmacology2016

Refractory chronic spontaneous urticaria and permanent atrial fibrillation associated with dental infection: Mere coincidence or something more to it?

Alicja Kasperska-Zajac, Alicja Grzanka, Jacek Kowalczyk, Magdalena Wyszyńska-Chłap, Grażyna Lisowska, Jacek Kasperski, Jerzy Jarząb, Maciej Misiołek, Zbigniew Kalarus

Open access · bronzeAbstract readCase ReportsLetter
In one paragraph

Article in International journal of immunopathology and pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. The relationship between circulating concentrations of interleukin 17 and C reactive protein in chronic spontaneous urticaria.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alicja Kasperska-ZajacDepartment of Internal Diseases, Dermatology and Allergology, Medical University of Silesia in Katowice, Poland alakasperska@gmail.com.
Alicja GrzankaDepartment of Internal Diseases, Dermatology and Allergology, Medical University of Silesia in Katowice, Poland.
Jacek KowalczykDepartment of Cardiology, Congenital Heart Disease and Electrotherapy, Silesian Medical University, Silesian Centre for Heart Diseases, Poland.
Magdalena Wyszyńska-ChłapDepartment of Prosthetic Dentistry in Bytom, Medical University of Silesia, Katowice, Poland.
Grażyna LisowskaChair and Clinical Department of Otolaryngology in Zabrze, Medical University of Silesia, Katowice, Poland.
Jacek KasperskiDepartment of Prosthetic Dentistry in Bytom, Medical University of Silesia, Katowice, Poland.
Jerzy JarząbDepartment of Internal Diseases, Dermatology and Allergology, Medical University of Silesia in Katowice, Poland.
Maciej MisiołekChair and Clinical Department of Otolaryngology in Zabrze, Medical University of Silesia, Katowice, Poland.
Zbigniew KalarusDepartment of Cardiology, Congenital Heart Disease and Electrotherapy, Silesian Medical University, Silesian Centre for Heart Diseases, Poland.
Medical University of Silesia · PLSilesian Center for Heart Disease · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Controversy surrounds the role of dental infection/inflammation in the oral cavity in chronic spontaneous urticaria (CSU) and atrial fibrillation (AF), which is mainly due to scarce literature in this area. Therefore, this case report and review of literature illustrate a possible association between the acute-phase response (APR) and clinical conditions, such as CSU and dental infection/inflammation of oral cavity and AF.We describe a 36-year-old man with an 8-year history of difficult-to-treat, uncontrolled CSU, co-existent with dental infection/inflammatory processes of oral cavity and permanent atrial fibrillation (AF). In the presented case, the most likely triggering or aggravating/maintaining factor of the symptoms was the inflammation/dental infection of the oral cavity because of rapid reduction of the urticarial symptoms, drug doses, and serum CRP levels after the dental therapy. Dental treatment may have a beneficial effect on the systemic inflammatory response, reducing/normalizing the circulating levels of APR markers. APR activation appears to worsen CSU course, early identification and treatment of infectious/inflammatory foci in the oral cavity would form the mainstay of supportive therapy for CU probably through reduction of the systemic inflammatory burden. APR associated with infectious/inflammatory foci in the oral cavity could be taken into account as a predisposing agents to AF.

Indexed as

Acute-Phase ReactionAdultAtrial FibrillationChronic DiseaseC-Reactive ProteinHumansInfectionsMaleTooth DiseasesUrticariaC-Reactive Proteinacute phase responseatrial fibrillationchronic spontaneous urticariaC-reactive proteindental infectioninflammation of oral cavity

Identifiers

PMID26634403
PMCPMC5806732
OpenAlexW2266906671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.