Evidence map›Paper›PMID 26634383›Full record

ArticleJournal of comparative effectiveness research2016

Comparing high-dimensional confounder control methods for rapid cohort studies from electronic health records.

Yen Sia Low, Blanca Gallego, Nigam Haresh Shah

Abstract readComparative Study
In one paragraph

Article in Journal of comparative effectiveness research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  14. Detecting Signals of Dietary Supplement Adverse Events from the CFSAN Adverse Event Reporting System (CAERS).AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019
    Article
  15. Characterizing drug-related adverse events by joint analysis of biomedical and genomic data: A case study of drug-induced pulmonary fibrosis.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2018
    Article
  16. On Interestingness Measures for Mining Statistically Significant and Novel Clinical Associations from EMRs.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2016
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yen Sia LowStanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA 94305, USA.
Blanca GallegoCenter for Health Informatics, Australian Institute of Health Innovation, Macquarie University, Sydney, Australia.
Nigam Haresh ShahStanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA 94305, USA.

Funding

STANFORD COMPOSITE(RMI)U54HG004028 · NHGRI · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2005 to 2014
$36.2M
Methods for generalized ontology terms enrichment analysisR01LM011369 · NLM · STANFORD UNIVERSITY · PI SHAH, NIGAM H · 2013 to 2020
$5.0M
Mining health data for drug safety profilesR01GM101430 · NIGMS · STANFORD UNIVERSITY · PI SHAH, NIGAM H · 2013 to 2017
$2.9M
NHGRI NIH HHS U54 HG004028NIGMS NIH HHS R01 GM101430NLM NIH HHS R01 LM011369
6 · The paper itself

Abstract

aimsElectronic health records (EHR), containing rich clinical histories of large patient populations, can provide evidence for clinical decisions when evidence from trials and literature is absent. To enable such observational studies from EHR in real time, particularly in emergencies, rapid confounder control methods that can handle numerous variables and adjust for biases are imperative. This study compares the performance of 18 automatic confounder control methods.

methodsMethods include propensity scores, direct adjustment by machine learning, similarity matching and resampling in two simulated and one real-world EHR datasets. RESULTS &

conclusionsDirect adjustment by lasso regression and ensemble models involving multiple resamples have performance comparable to expert-based propensity scores and thus, may help provide real-time EHR-based evidence for timely clinical decisions.

Indexed as

Confounding Factors, EpidemiologicAlgorithmsCohort StudiesElectronic Health RecordsHumansMachine LearningPropensity Scorebiasclinical decision supportcohort studiesconfoundingelectronic health recordsmachine learningpropensity scores

Identifiers

PMID26634383
PMCPMC4933592

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.