Evidence map›Paper›PMID 26634368›Full record

ReviewJournal of physiology and biochemistry2016

The role of dietary potassium in hypertension and diabetes.

Cem Ekmekcioglu, Ibrahim Elmadfa, Alexa L Meyer, Thomas Moeslinger

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of physiology and biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07025928 (Salt Intake and Blood Pressure Control in Adults With Essential Hypertension), which is not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07025928 narecruitingnot on this mapstarted 2026, after this paper: background citation

Salt Intake and Blood Pressure Control in Adults With Essential Hypertension

TypeinterventionalSponsorSun JingfengRan2026 to 2030Enrolled190ConditionsHypertensionArmsDecreased Salt High Potassium Tool (DSHP Tool)
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Meta-Analysis of Potassium Intake and the Risk of Stroke.Journal of the American Heart Association · 2016
    Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Sodium salt substitution for blood pressure in adults with diabetes.The Cochrane database of systematic reviews · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Association between circulating micronutrient pattern, glycemic control, and insulin resistance in type 2 diabetes mellitus.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Observational
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cem EkmekciogluInstitute of Environmental Health, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria. cem.ekmekcioglu@meduniwien.ac.at.
Ibrahim ElmadfaDepartment of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria.
Alexa L MeyerDepartment of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria.
Thomas MoeslingerInstitute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria.
Medical University of Vienna · ATUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Potassium is an essential mineral which plays major roles for the resting membrane potential and the intracellular osmolarity. In addition, for several years, it has been known that potassium also affects endothelial and vascular smooth muscle functions and it has been repeatedly shown that an increase in potassium intake shifts blood pressure to a more preferable level. Meanwhile, the blood pressure lowering effects of potassium were presented in several intervention trials and summarized in a handful of meta-analyses. Furthermore, accumulating epidemiological evidence from, especially, the last decade relates low dietary potassium intake or serum potassium levels to an increased risk for insulin resistance or diabetes. However, intervention trials are required to confirm this association. So, in addition to reduction of sodium intake, increasing dietary potassium intake may positively affect blood pressure and possibly also glucose metabolism in many populations. This concise review not only summarizes the studies linking potassium to blood pressure and diabetes but also discusses potential mechanisms involved, like vascular smooth muscle relaxation and endothelium-dependent vasodilation or stimulation of insulin secretion in pancreatic β-cells, respectively.

Indexed as

Blood PressureDiabetes MellitusHumansHypertensionPotassiumPotassiumDiabetesEpidemiologyHypertensionMechanismsPhysiologyPotassium

Identifiers

PMID26634368
OpenAlexW2189217550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.