Evidence map›Paper›PMID 26634257›Full record

ArticleJournal of assisted reproduction and genetics2016

Is the wrong question being asked in infertility research?

Barbara Luke, Judy E Stern, Mark D Hornstein, Milton Kotelchuck, Hafsatou Diop, Howard Cabral, Eugene R Declercq

Open access · bronzeAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. DNA methylation differences at birth after conception through ART.Human reproduction (Oxford, England) · 2021
    Article
  15. Adverse Pregnancy Outcomes in Endometriosis - Myths and Realities.Current obstetrics and gynecology reports · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Barbara LukeDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, 965 Fee Road, East Fee Hall, Room 628, East Lansing, MI, 48824, USA. lukeb@msu.edu.ORCID http://orcid.org/0000-0002-0405-8133
Judy E SternDepartment of Obstetrics and Gynecology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Mark D HornsteinDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Milton KotelchuckMassGeneral Hospital for Children, Harvard Medical School, Boston, MA, USA.
Hafsatou DiopMassachusetts Department of Public Health, Boston, MA, USA.
Howard CabralDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Eugene R DeclercqDepartment of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA.
Boston University · USBrigham and Women's Hospital · USDartmouth College · USHarvard University · USMassachusetts Department of Public Health · USMichigan State University · US

Funding

Women's Health After Assisted Reproductive Technology: A Population-Based StudyR01HD067270 · NICHD · DARTMOUTH-HITCHCOCK CLINIC · PI DIOP, HAFSATOU, STERN, JUDY E · 2011 to 2020
$7.4M
Child Health After Assisted Reproductive Technology: A Population-Based StudyR01HD064595 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DECLERCQ, EUGENE R, DIOP, HAFSATOU · 2010 to 2014
$3.1M
NICHD NIH HHS R01 HD064595NICHD NIH HHS R01HD064595NICHD NIH HHS R01 HD067270NICHD NIH HHS R01HD067270
6 · The paper itself

Abstract

A persistent finding is that assisted reproductive technology (ART) is associated with compromised birth outcomes, including higher risks for prematurity, low birthweight, and congenital malformations, even among singletons. Over the past decade, our research group, the Massachusetts Outcome Study of Assisted Reproductive Technology (MOSART), has evaluated pregnancy and birth outcomes among three groups of women, those women treated with ART, those with indicators of subfertility but without ART treatment, and fertile women. We have also explored the influence of infertility-related diagnoses on outcomes for women and infants. Over the course of our research, we have changed our perspective from an original focus on ART treatment parameters as the primary cause of excess morbidity to one centered instead on the underlying infertility-related diagnoses. This paper summarizes the research findings from our group that support this change in focus for infertility-based research from a primary emphasis on ART treatment to greater attention to the contribution of preexisting pathology underlying the infertility and suggests directions for future analyses.

Indexed as

Pregnancy OutcomeReproductive Techniques, AssistedAdultFemaleHumansInfant, Low Birth WeightInfant, PrematureInfertilityPregnancyPremature BirthResearchAdverse pregnancy outcomesAssisted reproductive technologyChild healthWomen’s health

Identifiers

PMID26634257
PMCPMC4717139
OpenAlexW2189135255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.