Evidence map›Paper›PMID 26634176›Full record

ReviewInnovations in clinical neuroscience

Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain.

Atmaram Yarlagadda, Ganesh Acharya, Jayaprada Kasaraneni, Christiane S Hampe, Anita H Clayton

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Innovations in clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Atmaram YarlagaddaDr. Yarlagadda is Chief of Psychiatry, Behavioral Health Services, McDonald Army Health Center, Fort Eustis, Virginia; Dr. Acharya is Professor of Obstetrics and Gynecology, UiT-The Arctic University of Norway, Consultant Obstetrician and Gynecologist, University Hospital of North Norway, Tromsø, Norway, and Visiting Professor of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden; Dr. Kasaraneni is with Norton Healthcare, Louisville, Kentucky; Dr. Hampe is Associate Professor of Medicine, Department of Medicine, University of Washington, Seattle, Washington; and Dr. Clayton is Professor and Chair, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia.
Ganesh AcharyaDr. Yarlagadda is Chief of Psychiatry, Behavioral Health Services, McDonald Army Health Center, Fort Eustis, Virginia; Dr. Acharya is Professor of Obstetrics and Gynecology, UiT-The Arctic University of Norway, Consultant Obstetrician and Gynecologist, University Hospital of North Norway, Tromsø, Norway, and Visiting Professor of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden; Dr. Kasaraneni is with Norton Healthcare, Louisville, Kentucky; Dr. Hampe is Associate Professor of Medicine, Department of Medicine, University of Washington, Seattle, Washington; and Dr. Clayton is Professor and Chair, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia.
Jayaprada KasaraneniDr. Yarlagadda is Chief of Psychiatry, Behavioral Health Services, McDonald Army Health Center, Fort Eustis, Virginia; Dr. Acharya is Professor of Obstetrics and Gynecology, UiT-The Arctic University of Norway, Consultant Obstetrician and Gynecologist, University Hospital of North Norway, Tromsø, Norway, and Visiting Professor of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden; Dr. Kasaraneni is with Norton Healthcare, Louisville, Kentucky; Dr. Hampe is Associate Professor of Medicine, Department of Medicine, University of Washington, Seattle, Washington; and Dr. Clayton is Professor and Chair, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia.
Christiane S HampeDr. Yarlagadda is Chief of Psychiatry, Behavioral Health Services, McDonald Army Health Center, Fort Eustis, Virginia; Dr. Acharya is Professor of Obstetrics and Gynecology, UiT-The Arctic University of Norway, Consultant Obstetrician and Gynecologist, University Hospital of North Norway, Tromsø, Norway, and Visiting Professor of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden; Dr. Kasaraneni is with Norton Healthcare, Louisville, Kentucky; Dr. Hampe is Associate Professor of Medicine, Department of Medicine, University of Washington, Seattle, Washington; and Dr. Clayton is Professor and Chair, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia.
Anita H ClaytonDr. Yarlagadda is Chief of Psychiatry, Behavioral Health Services, McDonald Army Health Center, Fort Eustis, Virginia; Dr. Acharya is Professor of Obstetrics and Gynecology, UiT-The Arctic University of Norway, Consultant Obstetrician and Gynecologist, University Hospital of North Norway, Tromsø, Norway, and Visiting Professor of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden; Dr. Kasaraneni is with Norton Healthcare, Louisville, Kentucky; Dr. Hampe is Associate Professor of Medicine, Department of Medicine, University of Washington, Seattle, Washington; and Dr. Clayton is Professor and Chair, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia.
University Hospital of North Norway · NO

Funding

ISLET CELL MEMBRANE ANTIBODIES IN DIABTESR01DK026190 · NIDDK · UNIVERSITY OF WASHINGTON · PI HAMPE, CHRISTIANE S · 1986 to 2016
$4.9M
NIDDK NIH HHS R01 DK026190
6 · The paper itself

Abstract

Dopamine and prolactin exhibit opposite effects on lactation. However, a possible role for increased prolactin/dopamine ratio in postpartum mood and thought disorders and as a prognostic indicator of the mother's future mental health has not been well investigated. Postpartum depression is a serious condition with potentially devastating outcomes for both the mother and the infant. Early detection and treatment of this condition can have impressive results. Treatment options include antidepressant medications for mood disorders and use of antipsychotics and electroconvulsive therapy to address postpartum psychosis. Although there are obvious benefits of such treatments on the welfare of the mother and her child, broader implications of these treatments on lactation and child growth and development are not known. This review article explores a possible link between in-utero exposure to a high maternal prolactin/dopamine ratio and subsequent development of autism spectrum disorders. We hypothesize that a comprehensive, biologically oriented approach to the use of psychotropics in the regulation of neurotransmission during pre- and postpartum periods may result in better outcomes in this population.

Indexed as

autism spectrum disorders (ASD)dopaminefetal braingabapentingene expressionoxytocinPlacentaprolactin

Identifiers

PMID26634176
PMCPMC4655894
OpenAlexW2395251073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.