Evidence map›Paper›PMID 26634139›Full record

ArticleOxford medical case reports2015

CPT-11/bevacizumab for the treatment of refractory brain metastases in patients with HER2-neu-positive breast cancer.

S Sengupta, R Rojas, A Mahadevan, E Kasper, S Jeyapalan

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S SenguptaDepartment of Neurology , Harvard Medical School, Beth Israel Deaconess Medical Center , Boston, MA , USA.
R RojasDepartment of Neuroradiology , Harvard Medical School, Beth Israel Deaconess Medical Center , Boston, MA , USA.
A MahadevanDepartment of Radiation Oncology , Harvard Medical School, Beth Israel Deaconess Medical Center , Boston, MA , USA.
E KasperDepartment of Neurosurgery , Harvard Medical School, Beth Israel Deaconess Medical Center , Boston, MA , USA.
S JeyapalanDepartment of Neurology, Tuft Medical School, Tufts Medical Center, Boston, MA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nervous system relapse of patients with advanced HER2-neu-positive breast cancer is an increasing problem, with one-third of women developing brain metastases. Standard therapies using steroids, surgery and radiotherapy do not provide a lasting response. We evaluated CPT-11 and bevacizumab, which can both cross the blood-brain barrier, as combination therapy to treat HER2-neu-positive breast cancer with brain metastases.

Identifiers

PMID26634139
PMCPMC4664841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.