ArticleKorean journal of anesthesiology2015
Effective dose of dexmedetomidine to induce adequate sedation in elderly patients under spinal anesthesia.
Article in Korean journal of anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of different administration times of dexmedetomidine on the ED50 of sufentanil to inhibit the cardiovascular response in elderly patients with double lumen tracheal intubation: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Comparison of remimazolam and dexmedetomidine for conscious sedation in elderly patients undergoing dental implant surgery: a prospective randomized controlled trial.BMC geriatrics · 2025Trial
- Effect of low-dose dexmedetomidine to prolong spinal anesthesia in elderly patients: a prospective randomized controlled study.BMC anesthesiology · 2024Trial
- Optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough suppression: a prospective randomized controlled trial.BMC anesthesiology · 2019Trial
- The Impact of Sex on the Median Effective Dose of Dexmedetomidine for Preoperative Sedation in Adults Undergoing Upper Limb Surgery: An Up-and-Down Sequential Allocation Study.Drug design, development and therapy · 2026Article
- Dexmedetomidine Dosing Strategies in Sedation and Anesthesia: Pharmacokinetics, Safety, and Clinical Applications - A Narrative Review.Drug design, development and therapy · 2026Review
- Neurophysiological differences between dexmedetomidine sedation and natural sleep across the rodent lifespan: implications for aging and perioperative brain health.Anesthesiology and perioperative science · 2026Article
- Serious adverse effect of low-dose dexmedetomidine under spinal anesthesia: A case report and literature review.Qatar medical journal · 2025Article
- Dexmedetomidine for postoperative delirium in surgical patients: a mini-review of mechanisms, clinical evidence, and practical implementation.Frontiers in pharmacology · 2025Review
- Determining the Optimal Dosage of Dexmedetomidine for Smooth Emergence in Older Patients Undergoing Spinal Surgery: A Study of 44 Cases.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Predictors for Dexmedetomidine Requirement for Sedation under Regional Anesthesia.Journal of clinical medicine · 2024Article
- Dexmedetomidine: a real-world safety analysis based on FDA adverse event reporting system database.Frontiers in pharmacology · 2024Article
- Dexmedetomidine Combined With Patient-Controlled Analgesia for Palliative Sedation in Terminal-Stage Cancer Patients With Refractory Pain: A Retrospective Analysis of Nine Cases.Pain research & management · 2024Article
- Review
- BIS-guided sedation prevents the cough reaction of patients under general anaesthesia caused by extubation: a randomized controlled trial.Journal of anesthesia, analgesia and critical care · 2023Article
- Determination of the effective dose of dexmedetomidine to achieve loss of consciousness during anesthesia induction.Frontiers in medicine · 2023Article
- Effect of Dexmedetomidine for Palliative Sedation for Refractory Dyspnoea in Patients with Terminal-Stage Cancer.Cancer management and research · 2023Article
- Association of intraoperative dexmedetomidine use with postoperative hypotension in unilateral hip and knee arthroplasties: a historical cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Article
- Prevention of Bradycardia during Spinal Anesthesia under Dexmedetomidine Sedation in Older Adults.Journal of clinical medicine · 2022Article
- Median Effective Dose of Dexmedetomidine Inducing Bradycardia in Elderly Patients Determined by Up-and-Down Sequential Allocation Method.International journal of medical sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring sedation with dexmedetomidine, a dose adjustment may be needed based on the invasiveness of the procedure, the patient's general condition, and their age. We aim here to determine the effective dose (ED) of dexmedetomidine to induce an adequate depth of sedation in elderly patients undergoing spinal anesthesia.
methodsIn this study, 47 patients aged 65 years or older, American Society of Anesthesiologists physical status I or II, undergoing spinal anesthesia were included. Patients were randomly allocated into group I, II, III, IV or V according to the dexmedetomidine loading dose of 0.1, 0.3, 0.5, 0.7 and 1.0 µg/kg, respectively. After spinal anesthesia, the assigned loading dose of dexmedetomidine was infused intravenously for 10 minutes, after which infusion was maintained at a rate of 0.3 µg/kg/h for the next 10 minutes in all groups. We assessed the depth of sedation with the Ramsay sedation scale every five minutes and measured vital signs and the oxygen saturation. The ED50 and ED95 of dexmedetomidine to obtain adequate sedation (Ramsay sedation score ≥ 3) upon the completion of the loading dose were calculated with logistic regression.
resultsThe ED50 and ED95 of dexmedetomidine for adequate sedation were 0.29 µg/kg (95% confidence intervals [CI] 0.14-0.44) and 0.86 µg/kg (95% CI 0.52-1.20), respectively. Hypotension was frequent in groups IV, V compared to groups I, II, III (31.6 vs. 3.6%, P = 0.013).
conclusionsED95 of dexmedetomidine loading dose for adequate sedation is 0.86 µg/kg. However, dose higher than 0.5 µg/kg can lead to hemodynamic instability.
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