Evidence map›Paper›PMID 26633919›Full record

ArticleBehavioural neurology2015

Gender Differences in the Behavioral Symptom Severity of Prader-Willi Syndrome.

Masao Gito, Hiroshi Ihara, Hiroyuki Ogata, Masayuki Sayama, Nobuyuki Murakami, Toshiro Nagai, Tadayuki Ayabe, Yuji Oto, Kazutaka Shimoda

Open access · goldAbstract read
In one paragraph

Article in Behavioural neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  4. Light and sex modifybioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Masao GitoDepartment of Psychiatry, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan ; Ikezawa Hospital, 551 Shimo-Shingo, Hanyu, Saitama 348-0046, Japan ; Department of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kita-Kobayashi, Mibu-Machi, Shimotuka-Gun, Tochigi 321-0293, Japan.
Hiroshi IharaDepartment of Psychiatry, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan.
Hiroyuki OgataDepartment of Psychiatry, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan ; Department of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kita-Kobayashi, Mibu-Machi, Shimotuka-Gun, Tochigi 321-0293, Japan.
Masayuki SayamaDepartment of Psychiatry, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan.
Nobuyuki MurakamiDepartment of Pediatrics, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan.
Toshiro NagaiNakagawanosato Ryoiku Center, 222 Shimo-Akaiwa, Matsubushi-Machi, Kita-Katsushika-Gun, Saitama 343-0116, Japan.
Tadayuki AyabeDepartment of Pediatrics, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan.
Yuji OtoDepartment of Pediatrics, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan.
Kazutaka ShimodaDepartment of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kita-Kobayashi, Mibu-Machi, Shimotuka-Gun, Tochigi 321-0293, Japan.
Dokkyo Medical University Saitama Medical Center · JPDokkyo Medical University · JPAizawa Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study measured gender differences in Prader-Willi syndrome (PWS) in regard to the severity of behavioral symptoms.

methodsThe Food Related Problem Questionnaire (FRPQ), the Aberrant Behavior Checklist Japanese Version, the Childhood Routines Inventory, the Pervasive Developmental Disorders Autism Society Japan Rating Scale, and Japanese ADHD-RS were administered to PWS patients (45 males aged 6 to 58 and 37 females aged 6 to 45). To examine the effects that gender and genotype have on the severity of each symptom, two-way ANOVAs were conducted.

resultsSignificant interactions were found only in regard to FRPQ scores, such as FRPQ total score (F(1, 78) = 8.43, p < 0.01). The FRPQ of male deletion (DEL) individuals was higher than that of female DEL and male mUPD. The FRPQ of male maternal uniparental disomy (mUPD) was lower than that of female mUPD.

conclusionsIn terms of problem behaviors, routines, autistic behaviors, and hyperactivity, no significant differences were found. Food-related behaviors in DEL were more severe in males, although those in mUPD were less severe in males.

Indexed as

AdolescentAdultAttentionBehavioral SymptomsChildChild Development Disorders, PervasiveFeeding BehaviorFemaleHumansIntelligenceMaleMiddle AgedPrader-Willi SyndromePsychiatric Status Rating ScalesSeverity of Illness IndexSex Characteristics

Identifiers

PMID26633919
PMCPMC4655018
OpenAlexW2195240390

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.