ArticlePloS one2015
A Population-Based Acute Meningitis and Encephalitis Syndromes Surveillance in Guangxi, China, May 2007-June 2012.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
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- Case report: A toxoplasmic encephalitis in an immunocompromised child detected through metagenomic next-generation sequencing.Frontiers in public health · 2023Article
- Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis.Journal of microbiology (Seoul, Korea) · 2022Article
- Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study.The Lancet regional health. Western Pacific · 2022Article
- Update on Viral Infections Involving the Central Nervous System in Pediatric Patients.Children (Basel, Switzerland) · 2021Review
- Etiology of acute meningitis and encephalitis from hospital-based surveillance in South Kazakhstan oblast, February 2017-January 2018.PloS one · 2021Article
- Coagulase-negative staphylococci (CoNS) meningitis: a narrative review of the literature from 2000 to 2020.New microbes and new infections · 2020Review
- Clinical application and evaluation of metagenomic next-generation sequencing in suspected adult central nervous system infection.Journal of translational medicine · 2020Article
- The etiology of acute meningitis and encephalitis syndromes in a sentinel pediatric hospital, Shenzhen, China.BMC infectious diseases · 2019Article
- Management of Central Nervous System Infections, Vientiane, Laos, 2003-2011.Emerging infectious diseases · 2019Article
- Development and validation of an advanced fragment analysis-based assay for the detection of 22 pathogens in the cerebrospinal fluid of patients with meningitis and encephalitis.Journal of clinical laboratory analysis · 2019Article
- Prognostic factors in pediatric pneumococcal meningitis patients in mainland China: a retrospective multicenter study.Infection and drug resistance · 2019Article
- Acute Bacterial Meningitis in Qatar: A Hospital-Based Study from 2009 to 2013.BioMed research international · 2017Article
- Molecular epidemiological study of enteroviruses associated with encephalitis in children from Hangzhou, China.Medicine · 2016Article
- Molecular identification of human enteroviruses associated with aseptic meningitis in Yunnan province, Southwest China.SpringerPlus · 2016Article
- Clinico-epidemiological Study of Viral Acute Encephalitis Syndrome Cases and Comparison to Nonviral Cases in Children from Eastern India.Journal of global infectious diseasesArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAcute meningitis and encephalitis (AME) are common diseases with the main pathogens being viruses and bacteria. As specific treatments are different, it is important to develop clinical prediction rules to distinguish aseptic from bacterial or fungal infection. In this study we evaluated the incidence rates, seasonal variety and the main etiologic agents of AME, and identified factors that could be used to predict the etiologic agents.
methodsA population-based AME syndrome surveillance system was set up in Guigang City, Guangxi, involving 12 hospitals serving the study communities. All patients meeting the case definition were investigated. Blood and/or cerebrospinal fluid were tested for bacterial pathogens using culture or RT-PCR and serological tests for viruses using enzyme-linked immunosorbent assays. Laboratory testing variables were grouped using factor analysis. Multinomial logistic regression was used to predict the etiology of AME.
resultsFrom May 2007 to June 2012, the annual incidence rate of AME syndrome, and disease specifically caused by Japanese encephalitis (JE), other viruses, bacteria and fungi were 12.55, 0.58, 4.57, 0.45 and 0.14 per 100,000 population, respectively. The top three identified viral etiologic agents were enterovirus, mumps virus, and JE virus, and for bacteria/fungi were Streptococcus sp., Cryptococcus neoformans and Staphylococcus sp. The incidence of JE and other viruses affected younger populations and peaked from April to August. Alteration of consciousness and leukocytosis were more likely to be caused by JE, bacteria and fungi whereas CSF inflammation was associated with bacterial/fungal infection.
conclusionsWith limited predictive validity of symptoms and signs and routine laboratory tests, specific tests for JE virus, mumps virus and enteroviruses are required to evaluate the immunization impact and plan for further intervention. CSF bacterial culture cannot be omitted in guiding clinical decisions regarding patient treatment.
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