ArticleeLife2015
An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Who cites it
39 citing papers in PubMed, 60 citations in OpenAlex.
- Whale Müller glia create a permissive environment supporting retinal ganglion cell survival and neurite outgrowth.iScience · 2026Article
- Nematode extracellular protein interactome expands connections between signaling pathways.Cell genomics · 2026Article
- UNC5B is an isoform-dependent target for ectodomain shedding.Journal of biochemistry · 2025Article
- A multiplex extracellular interactome screening method employing high-avidity nanoparticles.bioRxiv : the preprint server for biology · 2025Article
- Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis.Nature communications · 2024Article
- Cell surface protein-protein interaction profiling for biological network analysis and novel target discovery.Life medicine · 2024Review
- Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways.bioRxiv : the preprint server for biology · 2024Article
- Differential Expression Analysis Identifies Candidate Synaptogenic Molecules for Wiring Direction-Selective Circuits in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Tissue-Targeted Transcriptomics Reveals SEMA3D Control of Hypoglossal Nerve Projection to Mouse Tongue Primordia.Acta histochemica et cytochemica · 2024Article
- Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling.Developmental cell · 2023Article
- Loss of flrt2 gene leads to microphthalmia in zebrafish.Biology open · 2023Article
- Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophagesFrontiers in immunology · 2023Article
- Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina.Frontiers in cellular neuroscience · 2023Article
- Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium.Arthritis research & therapy · 2022Article
- Article
- Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization.International journal of molecular sciences · 2021Article
- Synaptic recognition molecules in development and disease.Current topics in developmental biology · 2021Article
- Molecular mechanisms regulating synaptic specificity and retinal circuit formation.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project to the Medial Terminal Nucleus.Frontiers in molecular neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
In the inner plexiform layer (IPL) of the mouse retina, ~70 neuronal subtypes organize their neurites into an intricate laminar structure that underlies visual processing. To find recognition proteins involved in lamination, we utilized microarray data from 13 subtypes to identify differentially-expressed extracellular proteins and performed a high-throughput biochemical screen. We identified ~50 previously-unknown receptor-ligand pairs, including new interactions among members of the FLRT and Unc5 families. These proteins show laminar-restricted IPL localization and induce attraction and/or repulsion of retinal neurites in culture, placing them in an ideal position to mediate laminar targeting. Consistent with a repulsive role in arbor lamination, we observed complementary expression patterns for one interaction pair, FLRT2-Unc5C, in vivo. Starburst amacrine cells and their synaptic partners, ON-OFF direction-selective ganglion cells, express FLRT2 and are repelled by Unc5C. These data suggest a single molecular mechanism may have been co-opted by synaptic partners to ensure joint laminar restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.