ArticleNursing research
Individual Differences Among Children in Sucrose Detection Thresholds: Relationship With Age, Gender, and Bitter Taste Genotype.
Article in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03972176 (Determination of Perinatal Exposure to Non-caloric Sweeteners. Implications for the Development of Preferences for Sweet Taste, and Weight Gain During the First Year of Life), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of Perinatal Exposure to Non-caloric Sweeteners. Implications for the Development of Preferences for Sweet Taste, and Weight Gain During the First Year of Life
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Pooled it
- New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.The American journal of clinical nutrition · 2019Pooled it
- Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review.Frontiers in genetics · 2019Pooled it
- No significant salt or sweet taste preference or sensitivity differences following ad libitum consumption of ultra-processed and unprocessed diets: a randomized controlled pilot study.Chemical senses · 2023Trial
- Trial
- Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.Scientific reports · 2021Trial
- Genetic Variants Influencing Taste Perception and Food Preferences: Current Evidence.Nutrients · 2026Review
- Reduced Fat Taste Sensitivity and Its Association with Childhood Obesity in Tunisian Children: A Cross-Sectional Study.Nutrients · 2025Article
- The Role of Diet and Hormones on Taste: Low Carb Compared With Low Fat Study Findings.Current developments in nutrition · 2025Article
- Gender Moderates the Associations Between Responsiveness to Alarming Oral Sensations, Depressive Symptoms, and Dietary Habits in Adolescents.Nutrients · 2025Article
- Novel gnd_v2 Fusion Tag and Engineered TEV Protease Enable Efficient Production of Brazzein.Journal of microbiology and biotechnology · 2024Article
- Understanding the determinants of sweet taste liking in the African and East Asian ancestry groups in the U.S.-A study protocol.PloS one · 2024Article
- Understanding the Determinants of Sweet Liking in the African and East Asian Ancestry Groups in the U.S. - A Study Protocol.Research square · 2023Article
- Article
- Article
- TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects.Nutrients · 2022Observational
- Probiotic dairy products and consumption preferences in terms of sweetness sensitivity and the occurrence of childhood obesity.Frontiers in psychology · 2022Article
- Comparing Taste Detection Thresholds across Individuals Following Vegan, Vegetarian, or Omnivore Diets.Foods (Basel, Switzerland) · 2021Article
- Associations between Infant Dietary Intakes and Liking for Sweetness and Fattiness Sensations in 8-to-12-Year-Old Children.Nutrients · 2021Article
- Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold (TDT) Test.Journal of visualized experiments : JoVE · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundLittle research has focused on whether there are individual differences among children in their sensitivity to sweet taste and, if so, the biological correlates of such differences.
objectivesOur goal was to understand how variations in children's sucrose detection thresholds relate to their age and gender, taste genotype, body composition, and dietary intake of added sugars.
methodsSucrose detection thresholds in 7- to 14-year-old children were tested individually using a validated, two-alternative, forced-choice, paired-comparison tracking method. Five genetic variants of taste genes were assayed: TAS1R3 and GNAT3 (sweet genes; one variant each) and the bitter receptor gene TAS2R38 (three variants). All children were measured for body weight and height. A subset of these children were measured for the percentage of body fat and waist circumference and provided added sugar intake by 24-hour dietary recall.
resultsSucrose thresholds ranged from 0.23 to 153.8 mM with most of the children completing the threshold task (216/235; 92%). Some children were biologically related (i.e., siblings), and for the genetic analysis, one sibling from each family was studied. Variants in the bitter but not the sweet genes were related to sucrose threshold and sugar intake; children with two bitter-sensitive alleles could detect sucrose at lower concentrations (F(2,165) = 4.55, p = .01; rs1726866) and reported eating more added sugar (% kcal; F(2, 62) = 3.64, p = .03) than did children with less sensitive alleles. Age, gender, and indices of obesity also were related to child-to-child differences in sucrose threshold; girls were more sensitive than boys (t(214) = 2.0, p = .05), older children were more sensitive than younger children (r(214) = -.16, p = .02), and fatter (r(84) = -.22, p = .05) or more centrally obese children (r(84) = -.26, p = .02) were more sensitive relative to others. DISCUSSION: Inborn differences in bitter sensitivity may affect childhood dietary sugar intake with long-term health consequences. There may be a more complex interplay between the developing bitter and sweet taste systems than previously understood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.