ArticleViruses2015
Incomplete LPS Core-Specific Felix01-Like Virus vB_EcoM_VpaE1.
Article in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Pooled it
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- Cell-free expression system: a promising platform for bacteriophage production and engineering.Microbial cell factories · 2025Review
- The structure of Shigella virus Sf14 reveals the presence of two decoration proteins and two long tail fibers.Communications biology · 2025Article
- PHEIGES: all-cell-free phage synthesis and selection from engineered genomes.Nature communications · 2024Article
- Control ofAntibiotics (Basel, Switzerland) · 2023Article
- Study of Combined Effect of Bacteriophage vB3530 and Chlorhexidine on the Inactivation of Pseudomonas aeruginosa.BMC microbiology · 2023Article
- Characterization of Phage vB_SalM_SPJ41 and the Reduction of Risk of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Substantiation of propitious "Enzybiotic" from two novel bacteriophages isolated from a wastewater treatment plant in Qatar.Scientific reports · 2022Article
- Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection.PLoS biology · 2021Article
- Novel Host Recognition Mechanism of the K1 Capsule-Specific Phage ofJournal of virology · 2021Article
- LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.Journal of virology · 2020Article
- Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages.Nature communications · 2020Article
- A major-capsid-protein-based multiplex PCR assay for rapid identification of selected virulent bacteriophage types.Archives of virology · 2019Article
- BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site.Nucleic acids research · 2019Article
- Complete Genome Sequence ofGenome announcements · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophages represent a valuable source for studying the mechanisms underlying virus-host interactions. A better understanding of the host-specificity of viruses at the molecular level can promote various phage applications, including bacterial diagnostics, antimicrobial therapeutics, and improve methods in molecular biology. In this study, we describe the isolation and characterization of a novel coliphage, vB_EcoM_VpaE1, which has different host specificity than its relatives. Morphology studies, coupled with the results of genomic and proteomic analyses, indicate that vB_EcoM_VpaE1 belongs to the newly proposed genus Felix01likevirus in the family Myoviridae. The genus Felix01likevirus comprises a group of highly similar phages that infect O-antigen-expressing Salmonella and Escherichia coli (E. coli) strains. Phage vB_EcoM_VpaE1 differs from the rest of Felix01-like viruses, since it infects O-antigen-deficient E. coli strains with an incomplete core lipopolysaccharide (LPS). We show that vB_EcoM_VpaE1 can infect mutants of E. coli that contain various truncations in their LPS, and can even recognize LPS that is truncated down to the inner-core oligosaccharide, showing potential for the control of rough E. coli strains, which usually emerge as resistant mutants upon infection by O-Ag-specific phages. Furthermore, VpaE1 can replicate in a wide temperature range from 9 to 49 °C, suggesting that this virus is well adapted to harsh environmental conditions. Since the structural proteins of such phages tend to be rather robust, the receptor-recognizing proteins of VpaE1 are an attractive tool for application in glycan analysis, bacterial diagnostics and antimicrobial therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.