Evidence map›Paper›PMID 26633307›Full record

ArticlePloS one2015

Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation.

Ashraf S A El-Sayed, Marwa A Yassin, Gul Shad Ali

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. First report on Fusarium oxysporum, an endophyte of Polygala sinaicum: isolation and identification of biologically active natural metabolites.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Production, bioprocess optimization and γ-irradiation ofBiotechnology reports (Amsterdam, Netherlands) · 2021
    Article
  14. Biosynthesis and Anti-Mycotoxigenic Activity ofMolecules (Basel, Switzerland) · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashraf S A El-SayedBotany and Microbiology Department, Faculty of Science, Zagazig University, 44519, Zagazig, Egypt.
Marwa A YassinBotany and Microbiology Department, Faculty of Science, Zagazig University, 44519, Zagazig, Egypt.
Gul Shad AliMid-Florida Research and Education Center, Department of Plant Pathology, University of Florida, Apopka, Florida 32703, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aspergillus flavipes has received considerable interest due to its potential to produce therapeutic enzymes involved in sulfur amino acid metabolism. In natural habitats, A. flavipes survives under sulfur limitations by mobilizing endogenous and exogenous sulfur to operate diverse cellular processes. Sulfur limitation affects virulence and pathogenicity, and modulates proteome of sulfur assimilating enzymes of several fungi. However, there are no previous reports aimed at exploring effects of sulfur limitation on the regulation of A. flavipes sulfur metabolism enzymes at the transcriptional, post-transcriptional and proteomic levels. In this report, we show that sulfur limitation affects morphological and physiological responses of A. flavipes. Transcription and enzymatic activities of several key sulfur metabolism genes, ATP-sulfurylase, sulfite reductase, methionine permease, cysteine synthase, cystathionine β- and γ-lyase, glutathione reductase and glutathione peroxidase were increased under sulfur starvation conditions. A 50 kDa protein band was strongly induced by sulfur starvation, and the proteomic analyses of this protein band using LC-MS/MS revealed similarity to many proteins involved in the sulfur metabolism pathway.

Indexed as

TranscriptomeAspergillusCysteine SynthaseGene Expression Regulation, BacterialGlutathione ReductaseGlutathione TransferaseOxidoreductases Acting on Sulfur Group DonorsProteomicsSulfate AdenylyltransferaseSulfite Reductase (NADPH)SulfurTandem Mass SpectrometryCysteine SynthaseGlutathione ReductaseGlutathione TransferaseOxidoreductases Acting on Sulfur Group DonorsSulfate AdenylyltransferaseSulfite Reductase (NADPH)Sulfur

Identifiers

PMID26633307
PMCPMC4669086

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.