ArticleAngewandte Chemie (International ed. in English)2016
Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Renal-clearable fluorescent probe for early detection of pancreatic cancer in living murine models.Science advances · 2026Article
- MRI tumor imaging by click chemistry using Gd(iii)-DOTA-DBCO and AcRSC advances · 2026Article
- Towards Metabolic Organic Radical Contrast Agents (mORCAs) for Magnetic Resonance Imaging.Molecules (Basel, Switzerland) · 2025Article
- In Situ Glycan Analysis and Editing in Living Systems.JACS Au · 2024Review
- The Application of Bio-orthogonality for In Vivo Animal Imaging.Chemical & biomedical imaging · 2023Review
- Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry.Signal transduction and targeted therapy · 2022Review
- Metabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides.Bioconjugate chemistry · 2022Article
- Imidazolium labelling permits the sensitive mass-spectrometric detection ofChemical communications (Cambridge, England) · 2021Article
- Metabolic glycan labelling for cancer-targeted therapy.Nature chemistry · 2020Review
- Biomedical applications of copper-free click chemistry:Chemical science · 2019Review
- Visualizing glycans on single cells and tissues-Visualizing glycans on single cells and tissues.Current opinion in chemical biology · 2017Review
- Physiological Effects of Ac4ManNAz and Optimization of Metabolic Labeling for Cell Tracking.Theranostics · 2017Article
- Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Review
- Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Glycosylation is a ubiquitous post-translational modification, present in over 50% of the proteins in the human genome, with important roles in cell-cell communication and migration. Interest in glycome profiling has increased with the realization that glycans can be used as biomarkers of many diseases, including cancer. We report here the first tomographic imaging of glycosylated tissues in live mice by using metabolic labeling and a gadolinium-based bioorthogonal MRI probe. Significant N-azidoacetylgalactosamine dependent T1 contrast was observed in vivo two hours after probe administration. Tumor, kidney, and liver showed significant contrast, and several other tissues, including the pancreas, spleen, heart, and intestines, showed a very high contrast (>10-fold). This approach has the potential to enable the rapid and non-invasive magnetic resonance imaging of glycosylated tissues in vivo in preclinical models of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.