ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 31 citations in OpenAlex.
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- Review
- An epigenetic candidate-gene association study of parental styles in suicide attempters with substance use disorders.Addiction biology · 2024Article
- Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.BMC neuroscience · 2023Review
- A Stress Protein-Based Suicide Prediction Score and Relationship to Reported Early-Life Adversity and Recent Life Stress.The international journal of neuropsychopharmacology · 2023Article
- Early life adversity and increased antisocial and depressive tendencies in young adults with family histories of alcohol and other substance use disorders: Findings from the Family Health Patterns project.Addictive behaviors reports · 2022Article
- Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From theFrontiers in human neuroscience · 2022Article
- Respiration rate during a stress task moderates neuroticism and perceived stress in older adults.Current issues in personality psychology · 2022Article
- Early life adversity and appetite hormones: The effects of smoking status, nicotine withdrawal, and relapse on ghrelin and peptide YY during smoking cessation.Addictive behaviors · 2021Article
- Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction.Neuropharmacology · 2021Review
- Self-regulation and emotional reactivity in infants with prenatal exposure to opioids and alcohol.Early human development · 2020Article
- Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure.Stress (Amsterdam, Netherlands) · 2019Review
- Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes.Alcoholism, clinical and experimental research · 2019Article
- The role of genetics in stress effects on health and addiction.Current opinion in psychology · 2019Review
- The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder - A systematic review.Schizophrenia research. Cognition · 2019Review
- Early life adversity and increased delay discounting: Findings from the Family Health Patterns project.Experimental and clinical psychopharmacology · 2019Article
- Is the HPA Axis as Target for Depression Outdated, or Is There a New Hope?Frontiers in psychiatry · 2019Review
- Impact of early life adversity on the stress biobehavioral response during nicotine withdrawal.Psychoneuroendocrinology · 2018Article
- A BRIEF INTRODUCTION TO THE NEUROGENETICS OF COGNITION-EMOTION INTERACTIONS.Current opinion in behavioral sciences · 2018Article
- Precision pharmacotherapy: psychiatry's future direction in preventing, diagnosing, and treating mental disorders.Pharmacogenomics and personalized medicine · 2018Review
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Authors and funding
8 authors at 6 institutions in 1 country.
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Abstract
Exposure to stress during critical periods of development can have adverse effects on adult health behaviors, and genetic vulnerabilities may enhance these stress effects. We carried out an exploratory examination of psychological, physiological, and behavioral characteristics of 252 healthy young adults for the impact of early-life adversity (ELA) in relation to the G-to-A single nucleotide polymorphism (SNP), rs9296158, of the FKBP5 gene. FKBP5 is a molecular cochaperone that contributes to the functional status of the glucocorticoid receptor (GR) and to the quality of corticosteroid signaling. FKBP5 expression is upregulated by cortisol exposure during stressful episodes, with greater upregulation seen in A-allele carriers. As such, FKBP5 expression and GR function may be environmentally sensitive in A-allele carriers and therefore suitable for the study of gene-by-environment (G × E) interactions. Compared with FKBP5, GG homozygotes (N=118), A-allele carriers (N = 132) without psychiatric morbidity had progressively worse performance on the Stroop color-word task with increasing levels of ELA exposure (Genotype × ELA, F=5.14, P=0.007), indicating a G × E interaction on working memory in early adulthood. In addition, heart rate response to mental stress was diminished overall in AA/AG-allele carriers (F=5.15, P=0.024). Diminished working memory and attenuated autonomic responses to stress are both associated with risk for alcoholism and other substance use disorders. The present data suggest that FKBP5 in the GR pathway may be a point of vulnerability to ELA, as seen in this group of non-traumatized young adults. FKBP5 is accordingly a potential target for more extensive studies of the impact of ELA on health and health behaviors in adulthood.
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