ArticlePloS one2015
Clinical Significance of Fronto-Temporal Gray Matter Atrophy in Executive Dysfunction in Patients with Chronic Kidney Disease: The VCOHP Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Transcriptional risk score for chronic kidney disease: relation to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between renal function and memory-related disease: evidence from the China Health and Retirement Longitudinal Study.Renal failure · 2025Article
- Cognitive Impairment in Chronic Kidney Disease Across Different Stages: The Role of Structural and Perfusion-Driven Functional Connectivity Changes.Brain and behavior · 2025Article
- Brain surface area and function alterations are correlated with cognition in patients with end-stage renal disease.Quantitative imaging in medicine and surgery · 2025Article
- More rapid progression of brain atrophy in patients on peritoneal dialysis compared with hemodialysis: The VCOHP Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Brain atrophy in patients on peritoneal dialysis treatment.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Cognitive Impairment and Brain Atrophy in Patients with Chronic Kidney Disease.Journal of clinical medicine · 2024Review
- Altered spontaneous brain activities in maintenance hemodialysis patients with cognitive impairment and the construction of cognitive function prediction models.Renal failure · 2023Article
- Cognitive impairment and microvascular function in end-stage renal disease.International journal of methods in psychiatric research · 2022Article
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- Association between the Estimated Glomerular Filtration Rate and Brain Atrophy in Older Adults.American journal of nephrology · 2022Article
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- Cognitive Dysfunction and Gait Abnormalities in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2021Article
- Cerebrovascular Disease and Cognition in Chronic Kidney Disease Patients.Frontiers in cardiovascular medicine · 2020Review
- The utility of a network-based clustering method for dimension reduction of imaging and non-imaging biomarkers predictive of Alzheimer's disease.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesIt is well known that cognitive impairment in patients with chronic kidney disease (CKD) is characterized by executive dysfunction, rather than memory dysfunction, although the precise mechanism of this remains to be elucidated. The purpose of the present study is to examine the correlation between gray matter volume (GMV) and executive function in CKD patients. DESIGN, SETTING, PARTICIPANTS, MEASUREMENTS: This cross-sectional study recruited 95 patients with non-dialysis-dependent CKD (NDD-CKD) with no history of cerebrovascular disease, who underwent brain magnetic resonance imaging (MRI) and Trail Making Test (TMT) in the VCOHP Study. The subjects underwent brain MRI and TMT part A (TMT-A) and part B (TMT-B). The segmentation algorithm from Statistical Parametric Mapping 8 software was applied to every T1-weighted MRI scan to extract tissue maps corresponding to gray matter, white matter, and cerebrospinal fluid. GMV was normalized by dividing by the total intracranial volume, calculated by adding GMV, white matter volume, and cerebrospinal fluid space volume. Then, normalized whole-brain GMV was divided into four categories of brain lobes; frontal, parietal, temporal, and occipital. We assessed the correlation between normalized GMV and TMT using multivariable regression analysis.
resultsNormalized whole-brain GMV was significantly inversely correlated to the scores of TMT-A, TMT-B, and ΔTMT (TMT-B minus TMT-A). These correlations remained significant even after adjusting for relevant confounding factors. Normalized frontal and temporal GMV, but not parietal and occipital GMV, were significantly inversely correlated with TMT-A, TMT-B, and ΔTMT using multivariable regression analysis.
conclusionsThe present study demonstrates the correlation between normalized GMV, especially in the frontal and temporal lobes, and executive function, suggesting that fronto-temporal gray matter atrophy might contribute to executive dysfunction in NDD-CKD.
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