ArticleMedicine2015
Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population.
Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Genetic and serum biomarkers of NSAID hypersensitivity reactions.Frontiers in pharmacology · 2025Article
- The Association ofAnalytical cellular pathology (Amsterdam) · 2025Article
- Vitamin D receptor and binding protein genes variants in patients with migraine.Annals of clinical and translational neurology · 2023Article
- Vitamin D and Restless Legs Syndrome: A Review of Current Literature.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Review
- Article
- Article
- Vitamin D Receptor and Binding Protein Gene Variants in Patients with Essential Tremor.Molecular neurobiology · 2022Article
- Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome.Journal of neurology · 2021Article
- Searching for Novel Candidate Biomarkers of RLS in Blood by Proteomic Analysis.Nature and science of sleep · 2021Article
- Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome.Frontiers in pharmacology · 2021Article
- Unraveling the Mysteries of Restless Leg Syndrome.Cureus · 2020Review
- Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots.Molecular biology reports · 2019Article
- IL1B polymorphism is associated with essential tremor in Chinese population.BMC neurology · 2019Article
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression.PloS one · 2019Article
- Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome.The pharmacogenomics journal · 2018Article
- Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management.Frontiers in aging neuroscience · 2017Review
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Authors and funding
20 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS.We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay.The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS.These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS.
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