Observational studyMedicine2015
A Population-Based 16-Year Study on the Risk Factors of Surgical Site Infection in Patients after Bone Grafting: A Cross-Sectional Study in Taiwan.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Risk factors for surgical site infections after orthopaedic surgery: A meta-analysis and systematic review.International wound journal · 2025Pooled it
- Free vascularized medial femoral condyle periosteal flaps in the ankle and foot region: A narrative review.Joint diseases and related surgery · 2024Pooled it
- The Role of Crosslinking Agents in the Development of Collagen-Hydroxyapatite Composite Materials for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2025Article
- ADHD and Risk of Precocious Puberty: Considering the Impact of MPH.Biomedicines · 2024Article
- The Association between Autism Spectrum Disorder and Precocious Puberty: Considering Effect Modification by Sex and Neuropsychiatric Comorbidities.Journal of personalized medicine · 2024Article
- Bone Regeneration in a Large Animal Model Featuring a Modular Off-the-Shelf Soft Callus Mimetic.Advanced healthcare materials · 2023Article
- Osseointegration for Lower-Extremity Amputees: Operative Considerations from the Plastic Surgeon's Perspective.JBJS reviews · 2022Article
- Biocompatible Nanocomposite Coatings Deposited via Layer-by-Layer Assembly for the Mechanical Reinforcement of Highly Porous Interconnected Tissue-Engineered Scaffolds.Bioengineering (Basel, Switzerland) · 2022Article
- Low Intensity Pulsed Ultrasound for Bone Tissue Engineering.Micromachines · 2021Review
- FDA-approved bone grafts and bone graft substitute devices in bone regeneration.Materials science & engineering. C, Materials for biological applications · 2021Review
- The Influence of an Occult Infection on the Outcome of Autologous Bone Grafting During Surgical Bone Reconstruction: A Large Single-Center Case-Control Study.Journal of inflammation research · 2021Article
- Incidence and risks for surgical site infection after closed tibial plateau fractures in adults treated by open reduction and internal fixation: a prospective study.Journal of orthopaedic surgery and research · 2020Article
- Early childhood general anesthesia exposure associated with later developmental delay: A national population-based cohort study.PloS one · 2020Observational
- [Changes in age distribution and frequency of comorbidities in patients in the occupational insurance association treatment process].Der Unfallchirurg · 2019Article
- Article
- Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients.Clinical interventions in aging · 2019Article
- Multicenter study of patients' preferences and concerns regarding the origin of bone grafts utilized in dentistry.Patient preference and adherence · 2019Article
- Association of Body Mass Index With Infectious Complications in Free Tissue Transfer for Head and Neck Reconstructive Surgery.JAMA otolaryngology-- head & neck surgery · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone grafting is a commonly used orthopedic surgical procedure that will provide bone formation in bone defects or regions of defective bone healing. A major complication following bone grafting is a postoperative recipient graft site infection that is associated with substantial mortality and increased use of medical resources. The purpose of the study was to identify the risk factors associated with infection after bone-grafting surgery.Data from 1,303,347 patients listed in the Taiwan National Health Insurance Research Database (NHIRD) and admitted to hospitals from 1997 through 2012 who underwent primary bone grafting (mean age: 46.57 years old; mean length of hospital stay: 8.04 days) were analyzed. The incidence of infection by age, hospital stay, gender, income, chronic disease (tuberculosis [TB]; diabetes mellitus [DM]; acquired immunodeficiency syndrome [AIDS]), fracture complications (nonunion; delayed union fracture), types of graft and hospital was evaluated.Three percent of the patients developed a postoperative recipient graft site infection. Multivariable analysis revealed that patients were more likely to develop a post bone-grafting surgery infection if they were older, had a longer hospital stay, were male, had a lower income, or had comorbid TB, DM, or AIDS. Patients were more likely to develop an infection if they had a nonunion, an alloplast graft, or treated in a local clinic.Our findings should provide a clinically relevant reference for surgeons who perform bone grafting. Patients should be informed of the potential risks.
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