Trial reportScientific reports2015
Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic and Meta-analytic Review of Neural Correlates of Functional Outcome in Schizophrenia.Schizophrenia bulletin · 2017Pooled it
- Quality of life assessment in individuals with schizophrenia: a COSMIN-based systematic review of S-QoL41 and S-QoL18 incorporating neurobiological support.EClinicalMedicine · 2026Review
- Reimagining patient-reported outcomes in the age of generative AI.NPJ digital medicine · 2025Review
- Involuntary Hospitalizations in an Italian Acute Psychiatric Ward: A 6-Year Retrospective Analysis.Patient preference and adherence · 2023Article
- Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia.Translational psychiatry · 2022Article
- Enhanced Resting-State Functional Connectivity of the Nucleus Accumbens in First-Episode, Medication-Naïve Patients With Early Onset Schizophrenia.Frontiers in neuroscience · 2022Article
- Differences on Quality of Life of Patients with Schizophrenia: A Multicentric Study from Three Latin-America Countries.Culture, medicine and psychiatry · 2019Article
- Modernizing quality of life assessment: development of a multidimensional computerized adaptive questionnaire for patients with schizophrenia.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Caregiver's quality of life and its positive impact on symptomatology and quality of life of patients with schizophrenia.Health and quality of life outcomes · 2017Article
- Psychometric properties of the Ruminative Response Scale-short form in a clinical sample of patients with major depressive disorder.Patient preference and adherence · 2017Article
Corrections and comments
- Erratum issuedCorrigendum: Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study.2016 · Catherine, Faget-Agius [corrected to Faget-Agius, Catherine]; Jonathan, Wirsich [corrected to Wirsich, Jonathan]; Jean-Philippe, Ranjeva [corrected to Ranjeva, Jean-Philippe]; Raphaelle, Richieri [corrected to Richieri, Raphaelle]; Elisabeth, Soulier [corr
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the secondary visual cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p < 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker.
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