ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Procoagulant and fibrinolytic activity after polytrauma in rat.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis.Critical care (London, England) · 2021Pooled it
- Can tranexamic acid reduce the blood transfusion rate in patients undergoing percutaneous nephrolithotomy? A systematic review and meta-analysis.The Journal of international medical research · 2020Pooled it
- Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT.Health technology assessment (Winchester, England) · 2021Trial
- Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.Lancet (London, England) · 2017Trial
- Trial
- Trauma and Hemorrhage Lead to An Elevation in Fecal Hort-Chain Fatty Acids.Shock (Augusta, Ga.) · 2026Article
- Prolyl hydroxylase domain inhibitor is an effective pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock.Scientific reports · 2024Article
- Experimental Models of Traumatic Injuries: Do They Capture the Coagulopathy and Underlying Endotheliopathy Induced by Human Trauma?International journal of molecular sciences · 2023Review
- Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding.Science translational medicine · 2022Article
- Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes.Medicines (Basel, Switzerland) · 2021Review
- Evaluation of the gut microbiome in association with biological signatures of inflammation in murine polytrauma and shock.Scientific reports · 2021Article
- Tranexamic acid is effective in lower doses with infusion in total knee arthroplasty.Acta orthopaedica et traumatologica turcica · 2019Article
- Platelet dysfunction during trauma involves diverse signaling pathways and an inhibitory activity in patient-derived plasma.The journal of trauma and acute care surgery · 2019Article
- Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage.PloS one · 2019Article
- The roles of activated protein C in experimental trauma models.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Review
- Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury.Blood · 2018Review
- A clinically relevant and bias-controlled murine model to study acute traumatic coagulopathy.Scientific reports · 2018Article
- Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial.Wellcome open research · 2018Article
- A Retrospective Study of Transfusion Requirements in Trauma Patients Receiving Tranexamic Acid.Journal of trauma nursing : the official journal of the Society of Trauma NursesArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine whether trauma-induced coagulopathy is due to changes in 1) thrombin activity, 2) plasmin activity, and/or 3) factors that stimulate or inhibit thrombin or plasmin. Sprague-Dawley rats were anesthetized with 1-2% isoflurane/100% oxygen, and their left femoral artery and vein were cannulated. Polytrauma included right femur fracture, and damage to the small intestines, the left and medial liver lobes, and right leg skeletal muscle. Rats were then bled 40% of blood volume. Plasma samples were taken before trauma, and at 30, 60, 120, and 240 min. Polytrauma and hemorrhage led to a significant fall in prothrombin levels. However, circulating thrombin activity did not change significantly over time. Antithrombin III and α2 macroglobulin fell significantly by 2 h, then rose by 4 h. Soluble thrombomodulin was significantly elevated over the 4 h. Circulating plasmin activity, plasminogen, and D-dimers were elevated for the entire 4 h. Tissue plasminogen activator (tPA) was elevated at 30 min, then decreased below baseline levels after 1 h. Plasminogen activator inhibitor-1 was significantly elevated at 2-4 h. Neither tissue factor pathway inhibitor nor thrombin activatable fibrinolysis inhibitor changed significantly over time. The levels of prothrombin and plasminogen were 30-100 times higher than their respective active enzymes. Polytrauma and hemorrhage in rats lead to a fibrinolytic coagulopathy, as demonstrated by an elevation in plasmin activity, D-dimers, and tPA. These results are consistent with the observed clinical benefit of tranexamic acid in trauma patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.