ReviewCurrent aging science2016
Age-Related Sleep Disruption and Reduction in the Circadian Rhythm of Urine Output: Contribution to Nocturia?
Review in Current aging science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Nocturia Frequency and Its Association with Sleep Disturbance and Health-Related Quality of Life in a Urology Outpatient Population.Journal of clinical medicine · 2026Article
- Article
- The association between animal‑based and plant‑based protein intake with sleep quality, mood, anxiety, depression and stress among elderly: a cross-sectional study.BMC public health · 2025Article
- Adjustment to an Appropriate Bedtime Improves Nocturia in Older Adults: A Crossover Study.International journal of urology : official journal of the Japanese Urological Association · 2025Article
- Disruption of circadian rhythm as a potential pathogenesis of nocturia.Nature reviews. Urology · 2025Review
- Nocturia and obstructive sleep apnoea.Nature reviews. Urology · 2024Review
- Self-Nanoemulsifying/ Self-Assembled Cubic Nanoparticles Lyophilized Tablet: A Novel Biphasic Release Approach to Enhance the Bioavailability of a Lipophilic Drug.AAPS PharmSciTech · 2024Article
- Association between sleep regularity and arterial stiffness among middle-age adults in Southwestern China.BMC public health · 2024Article
- Sleep-independent circadian rhythm of aldosterone secretion in healthy young adults.Sleep health · 2024Article
- Impact of sleep on chronobiology of micturition among healthy older adults.American journal of physiology. Renal physiology · 2023Article
- Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration.npj aging · 2023Article
- Sleep in Normal Aging, Homeostatic and Circadian Regulation and Vulnerability to Sleep Deprivation.Brain sciences · 2021Review
- Managing Nocturia in Frail Older Adults.Drugs & aging · 2021Review
- Sleep, Sleep Disorders, and Sexual Dysfunction.The world journal of men's health · 2019Review
- Overnight Urge Perception in Nocturia Is Independent of Depression, PTSD, or Anxiety in a Male Veterans Administration Population.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening.Behavioural brain research · 2018Article
- Alterations in glutamatergic signaling contribute to the decline of circadian photoentrainment in aged mice.Neurobiology of aging · 2018Article
- Unexpected association between subclinical hearing loss and restorative sleep in a middle-aged and elderly Japanese population.BMC research notes · 2018Article
- Analysis of the Prevalence and Factors Associated with Nocturia in Adult Korean Men.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aging is associated with a marked increase in sleep complaints, and one factor causing sleep disruption is waking to void (nocturia). Urological surveys have found that few young adults report nocturia symptoms, but about half of those in their 60's and nearly 80% of older age groups are affected. Sleep surveys have found nocturia is a major cause of sleep disruption, with a majority of older adults with sleep disruption citing the need to void as the cause of their awakening. While much of the urological literature implies that nocturia causes sleep disruption, age-related changes in sleep depth and continuity may make it more likely that an older adult will wake in response to a filling bladder, or that an older adult will wake for another reason and then decide to void. There is also evidence that age-related changes in the amplitude of circadian rhythms contribute to nocturia. There is a well-described circadian rhythm in urine output, and evidence of circadian rhythmicity in some diuretic and anti-diuretic hormones. In this article, we describe how age-related changes in sleep depth and continuity and age-related changes in circadian rhythm amplitude may contribute to nocturia, and how nocturia in turn leads to sleep disruption. Better understanding of how changes in sleep and circadian rhythmicity impact nocturia may lead to improved treatments and better quality of life for older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.