Evidence map›Paper›PMID 26632356›Full record

ArticleThe American journal of bioethics : AJOB2015

Engineering Values Into Genetic Engineering: A Proposed Analytic Framework for Scientific Social Responsibility.

Pamela L Sankar, Mildred K Cho

Abstract read
In one paragraph

Article in The American journal of bioethics : AJOB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Attitudes toward genomics and precision medicine.Journal of clinical and translational science · 2021
    Article
  4. International Society of Psychiatric Genetics Ethics Committee: Issues facing us.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019
    Review
  5. Article
  6. The Culture of Biosafety, Biosecurity, and Responsible Conduct in the Life Sciences: A Comprehensive Literature Review.Applied biosafety : journal of the American Biological Safety Association · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Pamela L Sankara University of Pennsylvania.
Mildred K Chob Stanford University.
Stanford University · USUniversity of Pennsylvania · US

Funding

Center for Integration of Research on Genetics and EthicsP50HG003389 · NHGRI · STANFORD UNIVERSITY · PI CHO, MILDRED K. · 2004 to 2014
$9.9M
Toward a Framework for Policy Analysis of Microbiome ResearchR01HG004900 · NHGRI · STANFORD UNIVERSITY · PI CHO, MILDRED K., SANKAR, PAMELA L · 2009 to 2011
$1.2M
NHGRI NIH HHS P50 HG003389NHGRI NIH HHS P50HG003389NHGRI NIH HHS R01 HG004900NHGRI NIH HHS R01HG004900
6 · The paper itself

Abstract

Recent experiments have been used to "edit" genomes of various plant, animal and other species, including humans, with unprecedented precision. Furthermore, editing the Cas9 endonuclease gene with a gene encoding the desired guide RNA into an organism, adjacent to an altered gene, could create a "gene drive" that could spread a trait through an entire population of organisms. These experiments represent advances along a spectrum of technological abilities that genetic engineers have been working on since the advent of recombinant DNA techniques. The scientific and bioethics communities have built substantial literatures about the ethical and policy implications of genetic engineering, especially in the age of bioterrorism. However, recent CRISPr/Cas experiments have triggered a rehashing of previous policy discussions, suggesting that the scientific community requires guidance on how to think about social responsibility. We propose a framework to enable analysis of social responsibility, using two examples of genetic engineering experiments.

Indexed as

Social ResponsibilitySocial ValuesAnimalsBiological Science DisciplinesClustered Regularly Interspaced Short Palindromic RepeatsEthical AnalysisEthics, ResearchGenetic EngineeringHumansInfluenza A Virus, H5N1 SubtypeInfluenza, HumanResearch Personnelscientific social responsibility, science governance, scientific profession, genetic engineering, values engineering

Identifiers

PMID26632356
PMCPMC5020895
OpenAlexW2181691879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.