ArticleCancer medicine2016
Serum leptin, C-reactive protein, and cancer mortality in the NHANES III.
Article in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Repurposing the liquid-based Pap test for the detection of ovarian cancer protein biomarkers.Clinical proteomics · 2026Article
- Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older.Frontiers in aging · 2025Article
- Association of Low-Density Lipoprotein Cholesterol Levels with More than 20-Year Risk of Cardiovascular and All-Cause Mortality in the General Population.Journal of the American Heart Association · 2022Article
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- The Role of Diet Compared to Physical Activity on Women's Cancer Mortality: Results From the Third National Health and Nutrition Examination Survey.Frontiers in public health · 2022Article
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- Social isolation, inflammation, and cancer mortality from the National Health and Nutrition Examination Survey - a study of 3,360 women.BMC public health · 2021Article
- Novel Dietary and Lifestyle Inflammation Scores Directly Associated with All-Cause, All-Cancer, and All-Cardiovascular Disease Mortality Risks Among Women.The Journal of nutrition · 2021Article
- Income, inflammation and cancer mortality: a study of U.S. National Health and Nutrition Examination Survey mortality follow-up cohorts.BMC public health · 2020Article
- Elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis of patients with primary gastrointestinal stromal tumor.BMC gastroenterology · 2020Article
- Association of Leptin with Total and Free Testosterone: Results from the National Health and Nutrition Examination Surveys.Androgens: clinical research and therapeutics · 2020Article
- Association between obesity and biomarkers of inflammation and metabolism with cancer mortality in a prospective cohort study.Metabolism: clinical and experimental · 2019Article
- Leptin Regulation of Cancer Stem Cells in Breast and Gynecologic Cancer.Endocrinology · 2018Review
- Article
- Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies?Oxidative medicine and cellular longevity · 2017Review
- Serum leptin, C-reactive protein, and cancer mortality in the NHANES III.Cancer medicine · 2016Article
- Low energy density diet, weight loss maintenance, and risk of cardiovascular disease following a recent weight reduction program: A randomized control trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Plasma Leptin Levels and Risk of Incident Cancer: Results from the Dallas Heart Study.PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipokines, such as leptin, may affect cancer through its link with inflammation and obesity. We investigated the association between leptin, C-reactive protein, and risk of cancer death while accounting general and abdominal obesity. From the Third National Health and Examination Survey (NHANES III), we selected 5957 adult men and women with baseline measurements of serum leptin and CRP. Multivariable Cox regression was used to assess leptin and CRP levels (low, moderate, high) in relation to risk of cancer death. Stratification analyses were performed for obesity as defined by body mass index (BMI) and waist circumference. Fine and Gray regression was performed to account for death from cardiovascular disease and other causes as competing events. A total of 385 participants died of cancer during a mean follow-up of 18 years. After adjusting for BMI and waist circumference, an inverse association with log-transformed leptin was found for women, with a hazard ratio (HR) of 0.81 (95% confidence interval [CI]: 0.51-1.30) and 0.40 (95% CI: 0.24-0.68) for moderate and high compared to low levels of leptin, respectively; P(trend) = 0.0007). No association for leptin was observed in men, but higher CRP corresponded to increased risk of dying from cancer (HR: 2.98; 95% CI: 1.57-5.64 for the highest vs. lowest categories of CRP). Similar associations were observed with competing risk analysis also adjusted for BMI and waist circumference. Contrasting associations of serum leptin and CRP with cancer mortality may indicate sex-specific biological or environmental pathways linking obesity and cancer in men and women which warrant mechanistic investigations.
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Registered trials
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