ArticleJournal of biomechanical engineering2016
Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking.
Article in Journal of biomechanical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Strain heterogeneity measurement of mouse sclera by stereo digital image correlation under inflation testing.Optics and lasers in engineering · 2025Article
- Biomechanical Correlations Between the Cornea and the Optic Nerve Head.Investigative ophthalmology & visual science · 2024Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- Three-Dimensional Ultrasound Elastography Detects Age-Related Increase in Anterior Peripapillary Sclera and Optic Nerve Head Compression During IOP Elevation.Investigative ophthalmology & visual science · 2023Article
- Comparing Acute IOP-Induced Lamina Cribrosa Deformations Premortem and Postmortem.Translational vision science & technology · 2022Article
- Mechanical Deformation of Peripapillary Retina in Response to Acute Intraocular Pressure Elevation.Journal of biomechanical engineering · 2022Article
- Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy.Experimental eye research · 2022Article
- IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness.Experimental eye research · 2020Article
- Role of radially aligned scleral collagen fibers in optic nerve head biomechanics.Experimental eye research · 2020Article
- Collagen fiber interweaving is central to sclera stiffness.Acta biomaterialia · 2020Article
- Continuous intraocular pressure monitoring in patients with obstructive sleep apnea syndrome using a contact lens sensor.PloS one · 2020Article
- Scleral structure and biomechanics.Progress in retinal and eye research · 2020Review
- Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation.Investigative ophthalmology & visual science · 2018Article
- 3D Characterization of corneal deformation using ultrasound speckle tracking.Journal of innovative optical health sciences · 2017Article
- Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation.Investigative ophthalmology & visual science · 2017Article
- The impact of intraocular pressure on elastic wave velocity estimates in the crystalline lens.Physics in medicine and biology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Intraocular pressure (IOP) induced strains in the peripapillary sclera may play a role in glaucoma progression. Using inflation testing and ultrasound speckle tracking, the 3D strains in the peripapillary sclera were measured in nine human donor globes. Our results showed that the peripapillary sclera experienced through-thickness compression and meridional stretch during inflation, while minimal circumferential dilation was observed when IOP was increased from 10 to 19 mmHg. The maximum shear was primarily oriented in the through-thickness, meridional cross sections and had a magnitude slightly larger than the first principal strain. The tissue volume had minimal overall change, confirming near-incompressibility of the sclera. Substantial strain heterogeneity was present in the peripapillary region, with local high strain areas likely corresponding to structural heterogeneity caused by traversing blood vessels. These 3D strain characteristics provide new insights into the biomechanical responses of the peripapillary sclera during physiological increases of IOP. Future studies are needed to confirm these findings and investigate the role of these biomechanical characteristics in ocular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.