Evidence map›Paper›PMID 26631930›Full record

ReviewNature reviews. Neuroscience2016

Tau in physiology and pathology.

Yipeng Wang, Eckhard Mandelkow

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,202 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,202citing papers in PubMed, 4 pooled it
66.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,202 citing papers in PubMed, 4 syntheses or guidelines pooled it, 2,133 citations in OpenAlex.

  1. Pooled it
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  16. Tau Signaling in Injured Spinal Cord.bioRxiv : the preprint server for biology · 2026
    Article
  17. Review
  18. Review
  19. Article
  20. Article

1,142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yipeng WangGerman Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Eckhard MandelkowGerman Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Center of Advanced European Studies and Research · DEGerman Center for Neurodegenerative Diseases · DE

Funding

Medical Research CouncilWellcome Trust
6 · The paper itself

Abstract

Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is highly soluble and shows little tendency for aggregation. However, tau aggregation is characteristic of several neurodegenerative diseases known as tauopathies. The mechanisms underlying tau pathology and tau-mediated neurodegeneration are debated, but considerable progress has been made in the field of tau research in recent years, including the identification of new physiological roles for tau in the brain. Here, we review the expression, post-translational modifications and functions of tau in physiology and in pathophysiology.

Indexed as

AnimalsHumansPhosphorylationProtein Processing, Post-TranslationalTauopathiestau Proteinstau Proteins

Identifiers

PMID26631930
OpenAlexW2185034389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.