ArticleScientific reports2015
Ex vivo multiscale quantitation of skin biomechanics in wild-type and genetically-modified mice using multiphoton microscopy.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 95 citations in OpenAlex.
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- Fibrous network nature of plant cell walls enables tunable mechanics for development.Nature communications · 2025Article
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- Quantification of age-related changes in the structure and mechanical function of skin with multiscale imaging.GeroScience · 2024Article
- The biomechanics of wounds at physiologically relevant levels: Understanding skin's stress-shielding effect for the quantitative assessment of healing.Materials today. Bio · 2024Article
- A 20 MHz Repetition Rate, Sub-Picosecond Ti-Sapphire Laser for Fiber Delivery in Nonlinear Microscopy of the Skin.Life (Basel, Switzerland) · 2024Article
- Quantification of collagen fiber properties in alcoholic liver fibrosis using polarization-resolved second harmonic generation microscopy.Scientific reports · 2023Article
- Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases.Nature communications · 2023Article
- Development and qualification of clinical grade decellularized and cryopreserved human esophagi.Scientific reports · 2023Article
- Elastic fiber alterations and calcifications in calcific uremic arteriolopathy.Scientific reports · 2023Article
- Toughness of Network Materials: Structural Parameters Controlling Damage Accumulation.Journal of the mechanics and physics of solids · 2023Article
- A magnetically actuated, optically sensed tensile testing method for mechanical characterization of soft biological tissues.Science advances · 2023Article
- Improved segmentation of collagen second harmonic generation images with a deep learning convolutional neural network.Journal of biophotonics · 2022Article
- Selection signature analyses and genome-wide association reveal genomic hotspot regions that reflect differences between breeds of horse with contrasting risk of degenerative suspensory ligament desmitis.G3 (Bethesda, Md.) · 2022Article
- Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: anRoyal Society open science · 2022Article
- A mechanistic view on the aging human skin through ex vivo layer-by-layer analysis of mechanics and microstructure of facial and mammary dermis.Scientific reports · 2022Article
- Mechanobiology in the Comorbidities of Ehlers Danlos Syndrome.Frontiers in cell and developmental biology · 2022Review
- Quantitative structural imaging of keratoconic corneas using polarization-resolved SHG microscopy.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soft connective tissues such as skin, tendon or cornea are made of about 90% of extracellular matrix proteins, fibrillar collagens being the major components. Decreased or aberrant collagen synthesis generally results in defective tissue mechanical properties as the classic form of Elhers-Danlos syndrome (cEDS). This connective tissue disorder is caused by mutations in collagen V genes and is mainly characterized by skin hyperextensibility. To investigate the relationship between the microstructure of normal and diseased skins and their macroscopic mechanical properties, we imaged and quantified the microstructure of dermis of ex vivo murine skin biopsies during uniaxial mechanical assay using multiphoton microscopy. We used two genetically-modified mouse lines for collagen V: a mouse model for cEDS harboring a Col5a2 deletion (a.k.a. pN allele) and the transgenic K14-COL5A1 mice which overexpress the human COL5A1 gene in skin. We showed that in normal skin, the collagen fibers continuously align with stretch, generating the observed increase in mechanical stress. Moreover, dermis from both transgenic lines exhibited altered collagen reorganization upon traction, which could be linked to microstructural modifications. These findings show that our multiscale approach provides new crucial information on the biomechanics of dermis that can be extended to all collagen-rich soft tissues.
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