ArticleProceedings. Biological sciences2015
Y-linked variation for autosomal immune gene regulation has the potential to shape sexually dimorphic immunity.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Beyond sex determination: the Y chromosome in male cancers.Nature reviews. Cancer · 2026Review
- Non-additive transcriptional regulation underpins an additive survival trait in populations of Drosophila selected for increased post infection survival.BMC ecology and evolution · 2026Article
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- Support for Y-compensation of mother's curse affecting lifespan in Drosophila melanogaster.Heredity · 2024Article
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- Sex and gender affect immune aging.Frontiers in aging · 2023Review
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Antimicrobial Properties of a Peptide Derived from the Male Fertility Factor kl2 Protein ofCurrent issues in molecular biology · 2022Article
- Experimental evolution reveals sex-specific dominance for surviving bacterial infection in laboratory populations ofEvolution letters · 2021Article
- Evolution of genome structure in theGenome research · 2021Article
- Article
- An assessment of the immune costs associated with meiotic drive elements inProceedings. Biological sciences · 2019Article
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
- Y-chromosomes can constrain adaptive evolution via epistatic interactions with other chromosomes.BMC evolutionary biology · 2018Article
- Large-effect loci affect survival in Tasmanian devils (Sarcophilus harrisii) infected with a transmissible cancer.Molecular ecology · 2018Article
- Mitochondrial Dysfunction and Infection Generate Immunity-Fecundity Tradeoffs in Drosophila.Integrative and comparative biology · 2018Article
- The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila.BMC biology · 2017Article
- Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues.Proceedings. Biological sciences · 2017Article
- Intra- and intersexual differences in parasite resistance and female fitness tolerance in a polymorphic insect.Proceedings. Biological sciences · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexually dimorphic phenotypes arise from the differential expression of male and female shared genes throughout the genome. Unfortunately, the underlying molecular mechanisms by which dimorphic regulation manifests and evolves are unclear. Recent work suggests that Y-chromosomes may play an important role, given that Drosophila melanogaster Ys were shown to influence the regulation of hundreds of X and autosomal genes. For Y-linked regulatory variation (YRV) to facilitate sexually dimorphic evolution, however, it must exist within populations (where selection operates) and influence male fitness. These criteria have seldom been investigated, leaving the potential for dimorphic evolution via YRV unclear. Interestingly, male and female D. melanogaster differ in immune gene regulation. Furthermore, immune gene regulation appears to be influenced by the Y-chromosome, suggesting it may contribute to dimorphic immune evolution. We address this possibility by introgressing Y-chromosomes from a single wild population into an isogenic background (to create Y-lines) and assessing immune gene regulation and bacterial defence. We found that Y-line males differed in their immune gene regulation and their ability to defend against Serratia marcescens. Moreover, gene expression and bacterial defence were positively genetically correlated. These data indicate that the Y-chromosome has the potential to shape the evolution of sexually dimorphic immunity in this system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.