ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Excitatory Postrhinal Projections to Principal Cells in the Medial Entorhinal Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Distinct cortical spatial representations learned along disparate visual pathways.Science advances · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- The entorhinal spatial map integrates visual identity information of landmarks.Nature communications · 2026Article
- Cortical dissociation of spatial reference frames during place navigation.bioRxiv : the preprint server for biology · 2025Article
- Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex.Nature communications · 2025Article
- The medial entorhinal cortex encodes multisensory spatial information.Cell reports · 2024Article
- A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation.Nature communications · 2024Article
- The Anterior Thalamus Preferentially Drives Allocentric But Not Egocentric Orientation Tuning in Postrhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways.Frontiers in neuroanatomy · 2023Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- The anatomy and function of the postrhinal cortex.Behavioral neuroscience · 2022Review
- Spatial context and the functional role of the postrhinal cortex.Neurobiology of learning and memory · 2022Review
- Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex.The Journal of comparative neurology · 2021Article
- The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties.Neuroscience and biobehavioral reviews · 2020Review
- A sense of space in postrhinal cortex.Science (New York, N.Y.) · 2019Article
- Article
- Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation.Nature neuroscience · 2018Article
- Optical imaging of the rat brain suggests a previously missing link between top-down and bottom-up nervous system function.Neurophotonics · 2017Article
- Differential Contribution of CaFrontiers in cellular neuroscience · 2017Article
- Architecture of the Entorhinal Cortex A Review of Entorhinal Anatomy in Rodents with Some Comparative Notes.Frontiers in systems neuroscience · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The postrhinal cortex (POR) provides substantial input to the entorhinal cortex, mainly targeting superficial layers of the medial entorhinal cortex (MEC). Major inputs to POR originate in the visual and parietal cortex, thus providing neurons in MEC with a subset of cortical information relevant to their spatial firing properties. The POR takes a position that is comparable with that of the perirhinal cortex (PER) with regard to the lateral entorhinal cortex (LEC). Neurons in LEC and MEC show different functional properties likely reflecting differences in their respective inputs. Projections from PER to LEC exert a main inhibitory influence, which may relate to the sparse object-selective firing in LEC. In view of the continuous, spatially modulated firing properties of principal neurons in MEC, we tested in rats the hypothesis that projections from POR to MEC are functionally different from the PER-to-LEC counterpart in providing an excitatory drive to MEC. Our combined confocal and quantitative electron-microscopic observations indicated that POR projections target mainly principal cells in MEC, including neurons that project to the hippocampus. The ultrastructure of the majority of the synapses indicated that they are excitatory. Voltage-sensitive dye imaging in sagittal slices confirmed this morphologically derived conclusion, showing that the MEC network always responded with an overall depolarization, indicative for net excitatory transmission. In vitro single-cell recordings from principal cells showed only excitatory responses upon POR stimulation. These results show that POR provides an excitatory projection to MEC, differing fundamentally from the inhibitory projection of PER to LEC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.