ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Disruption of Epithalamic Left-Right Asymmetry Increases Anxiety in Zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- Sequential formation ofScience advances · 2026Article
- The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development.Frontiers in cell and developmental biology · 2025Article
- Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization.Frontiers in behavioral neuroscience · 2025Review
- Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates.Nature communications · 2024Article
- Article
- Valproic acid exposure affects social visual lateralization and asymmetric gene expression in zebrafish larvae.Scientific reports · 2024Article
- Brain regions controlling courtship behavior in the bluehead wrasse.Current biology : CB · 2023Article
- Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish.Scientific reports · 2022Article
- Zebrafish behavior as a gateway to nervous system assembly and plasticity.Development (Cambridge, England) · 2022Article
- Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel.Frontiers in cell and developmental biology · 2022Article
- Conserved and diverged asymmetric gene expression in the brain of teleosts.Frontiers in cell and developmental biology · 2022Article
- Zebrafish Tools for Deciphering Habenular Network-Linked Mental Disorders.Biomolecules · 2021Review
- Neuromodulation and Behavioral Flexibility in Larval Zebrafish: From Neurotransmitters to Circuits.Frontiers in molecular neuroscience · 2021Article
- Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations.Science advances · 2020Article
- Molecular and cellular determinants of motor asymmetry in zebrafish.Nature communications · 2020Article
- Brain and Behavioral Asymmetry: A Lesson From Fish.Frontiers in neuroanatomy · 2020Review
- Article
- Embryonic Ethanol Exposure Affects the Early Development, Migration, and Location of Hypocretin/Orexin Neurons in Zebrafish.Alcoholism, clinical and experimental research · 2019Article
- Convergence on reduced stress behavior in the Mexican blind cavefish.Developmental biology · 2018Article
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Differences between the left and right sides of the brain are found throughout the animal kingdom, but the consequences of altered neural asymmetry are not well understood. In the zebrafish epithalamus, the parapineal is located on the left side of the brain where it influences development of the adjacent dorsal habenular (dHb) nucleus, causing the left and right dHb to differ in their organization, gene expression, and connectivity. Left-right (L-R) reversal of parapineal position and dHb asymmetry occurs spontaneously in a small percentage of the population, whereas the dHb develop symmetrically following experimental ablation of the parapineal. The habenular region was previously implicated in modulating fear in both mice and zebrafish, but the relevance of its L-R asymmetry is unclear. We now demonstrate that disrupting directionality of the zebrafish epithalamus causes reduced exploratory behavior and increased cortisol levels, indicative of enhanced anxiety. Accordingly, exposure to buspirone, an anxiolytic agent, significantly suppresses atypical behavior. Axonal projections from the parapineal to the dHb are more variable when it is located on the right side of the brain, revealing that L-R reversals do not necessarily represent a neuroanatomical mirror image. The results highlight the importance of directional asymmetry of the epithalamus in the regulation of stress responses in zebrafish.
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