ArticleScientific reports2015
Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Orchestrating brain fluid dynamics: circadian regulation of CSF, glymphatic exchange, and waste clearance.Frontiers in cell and developmental biology · 2026Review
- Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Functional Connectivity Encodes Sound Locations by Lateralization Angles.Neuroscience bulletin · 2025Article
- Article
- Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.Nature biomedical engineering · 2023Article
- Fluids and flows in brain cancer and neurological disorders.WIREs mechanisms of disease · 2023Review
- Fluid transport in the brain.Physiological reviews · 2022Review
- Early changes to the extracellular space in the hippocampus under simulated microgravity conditions.Science China. Life sciences · 2022Article
- The Value of First-Order Features Based on the Apparent Diffusion Coefficient Map in Evaluating the Therapeutic Effect of Low-Intensity Pulsed Ultrasound for Acute Traumatic Brain Injury With a Rat Model.Frontiers in computational neuroscience · 2022Article
- Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis.Frontiers in neurology · 2021Review
- Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats.Scientific reports · 2020Article
- The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation.Aging and disease · 2020Article
- The Interstitial System of the Brain in Health and Disease.Aging and disease · 2020Review
- The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination.Aging and disease · 2019Article
- [Discovery of a new division system in brain and the regionalized drainage route of brain interstitial fluid].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- [Temporary acceleration of interstitial fluid drainage in excited brain region induced by movement].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Stimulation Modeling on Three-Dimensional Anisotropic Diffusion of MRI Tracer in the Brain Interstitial Space.Frontiers in neuroinformatics · 2019Article
- The Effect of Aquaporin-4 Knockout on Interstitial Fluid Flow and the Structure of the Extracellular Space in the Deep Brain.Aging and disease · 2018Article
- Quantitative Visualization of Dynamic Tracer Transportation in the Extracellular Space of Deep Brain Regions Using Tracer-Based Magnetic Resonance Imaging.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Imaging and Quantitative Analysis of the Interstitial Space in the Caudate Nucleus in a Rotenone-Induced Rat Model of Parkinson's Disease Using Tracer-based MRI.Aging and disease · 2017Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based method, water molecules in the interstitial fluid (ISF) could be specifically visualized in magnetic resonance (MR) imaging. We first observed the flow of ISF in the thalamus and caudate nucleus of a rat. The ISF flow was then modulated using a painful stimulation model. We demonstrated that the flow of ISF slowed significantly following neuronal activity in the thalamus. This reduction in ISF flow continued for hours and was not accompanied by slow diffusion into the ISS. This observation suggests that the transportation of substances into the ISS can be regulated with a selective external stimulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.