Evidence map›Paper›PMID 26631274›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2016

Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances.

Rita Haapakoski, Klaus P Ebmeier, Harri Alenius, Mika Kivimäki

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
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  15. Impact of air pollution exposure on the severity of major depressive disorder: Results from the DeprAir study.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Article
  16. Article
  17. New Light on Prions: Putative Role of PrPInternational journal of molecular sciences · 2024
    Review
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  19. Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Rita HaapakoskiDepartment of Epidemiology and Public Health, University College London, United Kingdom; Department of Psychiatry, University of Oxford, United Kingdom. Electronic address: r.haapakoski@ucl.ac.uk.
Klaus P EbmeierDepartment of Psychiatry, University of Oxford, United Kingdom.
Harri AleniusFinnish Institute of Occupational Health, Systems Toxicology Unit, Helsinki, Finland.
Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, United Kingdom; Department of Public Health, Faculty of Medicine, University of Helsinki, Finland.
University of Oxford · GBFinnish Institute of Occupational Health · FIUniversity of Helsinki · FI

Funding

Medical Research Council G1001354Medical Research Council MRC K013351Medical Research Council MR/K013351/1
6 · The paper itself

Abstract

The inflammation theory of depression, proposed over 20years ago, was influenced by early studies on T cell responses and since then has been a stimulus for numerous research projects aimed at understanding the relationship between immune function and depression. Observational studies have shown that indicators of immunity, especially C reactive protein and proinflammatory cytokines, such as interleukin 6, are associated with an increased risk of depressive disorders, although the evidence from randomized trials remains limited and only few studies have assessed the interplay between innate and adaptive immunity in depression. In this paper, we review current knowledge on the interactions between central and peripheral innate and adaptive immune molecules and the potential role of immune-related activation of microglia, inflammasomes and indoleamine-2,3-dioxygenase in the development of depressive symptoms. We highlight how combining basic immune methods with more advanced 'omics' technologies would help us to make progress in unravelling the complex associations between altered immune function and depressive disorders, in the identification of depression-specific biomarkers and in developing immunotherapeutic treatment strategies that take individual variability into account.

Indexed as

Adaptive ImmunityDepressive DisorderHumansImmunity, InnateInflammasomesMicrogliaT-LymphocytesInflammasomesAdaptive immunityCytokineDepressionInflammationInnate immunityOmics technologies

Identifiers

PMID26631274
PMCPMC4736094
OpenAlexW2186789877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.