Evidence map›Paper›PMID 26631107›Full record

ArticleTrends in hearing2015

Direct Intracochlear Acoustic Stimulation Using a PZT Microactuator.

Chuan Luo, Irina Omelchenko, Robert Manson, Carol Robbins, Elizabeth C Oesterle, Guo Zhong Cao, I Y Shen, Clifford R Hume

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in hearing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chuan LuoDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA Department of Precision Instruments, Tsinghua University, Beijing, China.
Irina OmelchenkoVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, USA.
Robert MansonDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.
Carol RobbinsVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, USA.
Elizabeth C OesterleVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, USA.
Guo Zhong CaoDepartment of Materials Science, University of Washington, Seattle, WA, USA.
I Y ShenDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA ishen@u.washington hume@uw.edu.
Clifford R HumeVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, USA VA Puget Sound, Seattle, WA, USA.
University of Washington · USTsinghua University · CN

Funding

UNIVERSITY OF WASHINGTON RESEARCH CORE CENTERP30DC004661 · NIDCD · UNIVERSITY OF WASHINGTON · PI WERNER, LYNNE A. · 2000 to 2014
$11.1M
HAIR CELL REGENERATION--REGULATORY SIGNALSR01DC003944 · NIDCD · UNIVERSITY OF WASHINGTON · PI OESTERLE, ELIZABETH C · 1999 to 2013
$3.3M
Afferent Innervation of the Postnatal CochleaK08DC006437 · NIDCD · UNIVERSITY OF WASHINGTON · PI HUME, CLIFFORD ROBERT · 2004 to 2008
$1.1M
NICHD NIH HHS P30 HD-02774NIDCD NIH HHS DC-006437NIDCD NIH HHS DC-03944NIDCD NIH HHS P30 DC-04661
6 · The paper itself

Abstract

Combined electric and acoustic stimulation has proven to be an effective strategy to improve hearing in some cochlear implant users. We describe an acoustic microactuator to directly deliver stimuli to the perilymph in the scala tympani. The 800 µm by 800 µm actuator has a silicon diaphragm driven by a piezoelectric thin film (e.g., lead-zirconium-titanium oxide or PZT). This device could also be used as a component of a bimodal acoustic-electric electrode array. In the current study, we established a guinea pig model to test the actuator for its ability to deliver auditory signals to the cochlea in vivo. The actuator was placed through the round window of the cochlea. Auditory brainstem response (ABR) thresholds, peak latencies, and amplitude growth were calculated for an ear canal speaker versus the intracochlear actuator for tone burst stimuli at 4, 8, 16, and 24 kHz. An ABR was obtained after removal of the probe to assess loss of hearing related to the procedure. In some animals, the temporal bone was harvested for histologic analysis of cochlear damage. We show that the device is capable of stimulating ABRs in vivo with latencies and growth functions comparable to stimulation in the ear canal. Further experiments will be necessary to evaluate the efficiency and safety of this modality in long-term auditory stimulation and its ability to be integrated with conventional cochlear implant arrays.

Indexed as

Cochlear ImplantsAcoustic StimulationAnimalsAuditory ThresholdCochlear ImplantationDisease Models, AnimalEvoked Potentials, Auditory, Brain StemFemaleGuinea PigsPiezosurgeryProsthesis DesignRandom AllocationSensitivity and SpecificitycochleaCochlear implantelectroacoustichearing aidhybridperilymphpiezoelectricPZT

Identifiers

PMID26631107
PMCPMC4771031
OpenAlexW2260832357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.