Evidence map›Paper›PMID 26631058›Full record

Trial reportJournal of negative results in biomedicine2015

Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study.

Mori J Krantz, Edward P Havranek, Rocio I Pereira, Brenda Beaty, Philip S Mehler, Carlin S Long

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of negative results in biomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00935766 (Latinos Using Cardio Health Actions to Reduce Risk), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00935766 phase3terminatednot on this map

Latinos Using Cardio Health Actions to Reduce Risk (LUCHAR): Effect of Omega-3 Fatty Acids on Vascular Function and Inflammation

TypeinterventionalSponsorDenver Health and Hospital AuthorityRan2009 to 2012Enrolled76ConditionsMetabolic Diseases, Endocrine System Diseases, Heart Disease, Vascular DiseasesArmsOmega-3, Placebo
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mori J KrantzCardiology Division, Denver Health Medical Center, 777 Bannock St., MC0960, Denver, CO, 80204, USA. mkrantz@dhha.org.
Edward P HavranekCardiology Division, Denver Health Medical Center, 777 Bannock St., MC0960, Denver, CO, 80204, USA. Edward.havranek@dhha.org.
Rocio I PereiraDepartment of Medicine, University of Colorado School of Medicine, 13001 E 17th Pl., Aurora, CO, 80045, USA. Rocio.pereira@ucdenver.edu.
Brenda BeatyColorado Health Outcomes Program, University of Colorado School of Medicine, 13199 E. Montview Blvd. Suite 300, Aurora, CO, 80045, USA. Brenda.beaty@ucdenver.edu.
Philip S MehlerDepartment of Medicine, University of Colorado School of Medicine, 13001 E 17th Pl., Aurora, CO, 80045, USA. Philip.Mehler@dhha.org.
Carlin S LongCardiology Division, Denver Health Medical Center, 777 Bannock St., MC0960, Denver, CO, 80204, USA. Clong@dhha.org.
University of Colorado Denver · USDenver Health Medical Center · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Latinos Using Cardio Health Actions to Reduce RiskU01HL079160 · NHLBI · DENVER HEALTH AND HOSPITAL AUTHORITY · PI HAVRANEK, EDWARD PAUL · 2004 to 2008
$2.9M
NCATS NIH HHS UL1 TR001082NHLBI NIH HHS U01 HL079160
6 · The paper itself

Abstract

backgroundOmega-3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies did not use treatment doses (3.36 g) of omega-3 fatty acids. Arterial stiffness measured by pulse wave velocity (PWV) predicts CVD events independent of standard risk factors. However, no therapy has been shown to reduce PWV in a blood pressure-independent manner. We assessed the effects of esterified omega-3 fatty acids on PWV and serum markers of inflammation among patients with hypertension. DESIGN AND

methodsWe performed a prospective, randomized; double-blinded pilot study of omega-3 fatty acids among 62 patients in an urban, safety net hospital. Patients received 3.36 g of omega-3 fatty acids vs. matched placebo daily for 3-months. The principal outcome measure was change in brachial-ankle PWV. Serum inflammatory markers associated with CVD risk were also assessed.

resultsThe majority (71 %) were of Latino ethnicity. After 3-months, mean change in arterial PWV among omega-3 and placebo groups was -97 cm/s vs. -33 cm/s respectively (p = 0.36 for difference, after multivariate adjustment for baseline age, systolic blood pressure, and serum adiponectin). Non-significant reductions in lipoprotein-associated phospholipase A2 (LpPLA2) mass and high sensitivity C-reactive protein (hsCRP) relative to placebo were also observed (p = 0.08, and 0.21, respectively).

conclusionHigh-dose omega-3 fatty acids did not reduce arterial PWV or markers of inflammation among patients within a Latino-predominant population with hypertension. CLINICAL

trial registrationNCT00935766 , registered July 8 2009.

Indexed as

Vascular StiffnessAgedDouble-Blind MethodFatty Acids, Omega-3FemaleHumansHypertensionMaleMiddle AgedPilot ProjectsProspective StudiesTreatment OutcomeFatty Acids, Omega-3

Identifiers

PMID26631058
PMCPMC4668614
OpenAlexW2193666498

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.