Evidence map›Paper›PMID 26631033›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.

Jing Guo, Xiaofang Yu, Jie Gu, Zongwu Lin, Guangyin Zhao, Fengkai Xu, Chunlai Lu, Di Ge

Abstract read
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  9. Contrast-enhanced computed tomography combined with Chitosan-FeExperimental and therapeutic medicine · 2018
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  15. srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.Journal of experimental & clinical cancer research : CR · 2016
    Article
  16. Article
  17. MicroRNA target for MACC1 and CYR61 to inhibit tumor growth in mice with colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jing GuoDepartment of Thoracic Surgery, Ningbo No.1 Hospital, Ningbo, Zhejiang Province, People's Republic of China.
Xiaofang YuDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Jie GuDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin RD, Shanghai, 200032, People's Republic of China.
Zongwu LinDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin RD, Shanghai, 200032, People's Republic of China.
Guangyin ZhaoShanghai No.1 Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Fengkai XuDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin RD, Shanghai, 200032, People's Republic of China.
Chunlai LuDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin RD, Shanghai, 200032, People's Republic of China. lu.chunlai@zs-hospital.sh.cn.
Di GeDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin RD, Shanghai, 200032, People's Republic of China. ge.di@zs-hospital.sh.cn.
Fudan University · CNZhongshan Hospital · CNNingbo No.6 Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CXC chemokines and their cognate receptors have been implicated wildly in cancer pathogenesis. In the present study, we report a critical cause relationship between CXCR4 expression and tumorigenesis in the setting of human esophageal squamous cell carcinoma (ESCC). In ESCC cells, CXCR4 expression was significantly higher than in human esophageal epithelial cells (HEEC). Reduction of CXCR4 in ESCC cells reduced cell proliferation and invasion in vitro and tumor growth in vivo. Among the potential downstream targets of CXCR4-CXCL12 are RhoA, Rac-1, and Cdc42, which are likely to contribute to the invasiveness of ESCC cells. Finally, we found that CXCR4-CXCL12/AKT axis regulates RhoA, Rac-1, and Cdc42 to modulate cell invasion and tumor metastasis. Together, these results demonstrate a role for CXCR4 in ESCC metastasis and progression and suggest potential targets for therapeutic intervention.

Indexed as

AnimalsCarcinogenesisCarcinoma, Squamous Cellcdc42 GTP-Binding ProteinCell Line, TumorCell ProliferationChemokine CXCL12Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaGene Expression Regulation, NeoplasticHumansMiceNeoplasm InvasivenessNeoplasm MetastasisOncogene Protein v-aktrac1 GTP-Binding Proteincdc42 GTP-Binding ProteinChemokine CXCL12CXCL12 protein, humanCXCR4 protein, humanOncogene Protein v-aktrac1 GTP-Binding ProteinRAC1 protein, humanReceptors, CXCR4rhoA GTP-Binding ProteinRHOA protein, humanChemokinesCXCR4Esophageal neoplasmsNeoplasm metastasisPI3K/AKT

Identifiers

PMID26631033
OpenAlexW2259137911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.