Evidence map›Paper›PMID 26630997›Full record

Trial reportEuropean radiology2016

Lowering iodinated contrast concentration in infrainguinal endovascular interventions: a three-armed randomized controlled non-inferiority trial.

Sjoerd Jens, Sanne M Schreuder, Diederik W De Boo, Lukas C van Dijk, Hans van Overhagen, Shandra Bipat, Mark J W Koelemay, Jim A Reekers

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06835127 (Feasibility Study of the Use of Ultra-low Dose Iodinated Contrast Agent for Endovascular Procedures in Patients With Chronic Limb-threatening Ischemia and Renal Impairment), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06835127 completednot on this mapstarted 2024, after this paper: background citation

Feasibility Study of the Use of Ultra-low Dose Iodinated Contrast Agent for Endovascular Procedures in Patients With Chronic Limb-threatening Ischemia and Renal Impairment

Typeobservational_patient_registrySponsorAttikon HospitalRan2024 to 2026Enrolled18ConditionsRenal Impairment, Limb Ischemia, CriticalArmsInfrainguinal peripheral endovascular revascularization
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Peripheral Arterial Interventions with Reduced Contrast Use: The Save Contrast Study.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026
    Article
  3. Article
  4. Three cases of fusion imaging in endovascular treatment of occlusive peripheral artery disease.Journal of vascular surgery cases and innovative techniques · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sjoerd JensDepartment of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. s.jens@amc.uva.nl.
Sanne M SchreuderDepartment of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Diederik W De BooDepartment of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Lukas C van DijkHagaZiekenhuis, Leyweg 275, 2545 CH, Den Haag, Netherlands.
Hans van OverhagenHagaZiekenhuis, Leyweg 275, 2545 CH, Den Haag, Netherlands.
Shandra BipatDepartment of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Mark J W KoelemayDepartment of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Jim A ReekersDepartment of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Academic Medical Center · NLHaga Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the influence of lowering iodinated contrast concentration on confidence of interventional radiologists in diagnosing and treating lesions during endovascular interventions in patients with symptomatic peripheral arterial disease (PAD).

methodsA randomized controlled non-inferiority trial was performed in 60 patients. Intervention was performed with contrast concentrations (in mg of iodine per mL, mgI/mL) of 300 (standard), 240, or 140 mgI/mL. Primary outcome was confidence (score 0-100 %) of radiologists in diagnosing and treating arterial lesions. Secondary outcomes were procedural iodine load and image quality (i.e. non-diagnostic, limited, diagnostic, exemplary).

resultsMedian confidence scores in diagnosing lesions were 100 % (range 81-100 %) for the 300 group (n = 21), 100 % (range 82-100 %) for the 240 group (n = 19), and 100 % (range 91-100 %) for the 140 group (n = 20) (both p = 1.00 compared to the 300 group). Median scores for treating lesions in the 240 and 140 groups, 100 % (range 79-100 %, p = 0.40), and 100 % (range 63-100 %, p = 0.25), respectively, were not lower compared to the 300 group (median 100 %, range 78-100 %). Procedural iodine load was lower in the 240 (24.3 ± 7.6 g, p = 0.022) and 140 groups (17.8 ± 5.6 g, p < 0.001) compared to the 300 group (29.7 ± 6.3 g). Image quality was diagnostic for all groups.

conclusionUsing iodine contrast of 140 mgI/mL for diagnosis and interventions in PAD patients significantly reduces administered iodine load without compromising image quality. Future use of lower iodine dose is recommended. KEY POINTS: • Lower iodinated contrast concentration during endovascular intervention does not decrease radiologist's confidence. • Image quality of standardized angiographies remains diagnostic using 140 mgI/mL iodinated contrast concentration. • Iodine load during intervention can be decreased by >40 % when using 140 mgI/mL. • Implementing the use of a lower iodinated contrast concentration will reduce the costs of the procedure.

Indexed as

AgedAged, 80 and overAngiographyArterial Occlusive DiseasesConstriction, PathologicContrast MediaDouble-Blind MethodFemaleFemoral ArteryHumansIodineMaleMiddle AgedPeripheral Arterial DiseasePopliteal ArteryProspective StudiesContrast MediaIodineAngiographyContrast mediaCritical limb ischemiaIntermittent claudicationPeripheral arterial disease

Identifiers

PMID26630997
PMCPMC4927610
OpenAlexW2256160397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.