Evidence map›Paper›PMID 26630974›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

A combination of low serum concentrations of vitamins K1 and D is associated with increased risk of hip fractures in elderly Norwegians: a NOREPOS study.

T E Finnes, C M Lofthus, H E Meyer, A J Søgaard, G S Tell, E M Apalset, C Gjesdal, G Grimnes, B Schei, R Blomhoff and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Short-Term Impact of Sleeve Gastrectomy on Bone Health.Mediterranean journal of rheumatology · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Role of Vitamin K in Bone and Muscle Metabolism.Calcified tissue international · 2023
    Review
  17. Interaction between Dietary Vitamin DAquaculture nutrition · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

T E FinnesDepartment of Internal Medicine, Innlandet Hospital Trust, Skolegata 32, N-2318, Hamar, Norway. trine_finnes@yahoo.com.
C M LofthusDepartment of Endocrinology, Oslo University Hospital, Oslo, Norway.
H E MeyerInstitute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
A J SøgaardDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
G S TellDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
E M ApalsetDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
C GjesdalDepartment of Rheumatology, Haukeland University Hospital, Bergen, Norway.
G GrimnesDepartment of Clinical Medicine, Arctic University of Norway, Tromsø, Norway.
B ScheiDepartment of Public Health and General Practice Norwegian, University of Science and Technology, Trondheim, Norway.
R BlomhoffDepartment of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway.
S O SamuelsenDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
K HolvikDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Norwegian Institute of Public Health · NOHaukeland University Hospital · NOOslo University Hospital · NONorwegian University of Science and Technology · NOUniversity Hospital of North Norway · NOUniversity of Bergen · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe present study investigated the risk of incident hip fractures according to serum concentrations of vitamin K1 and 25-hydroxyvitamin D in elderly Norwegians during long-term follow-up. The results showed that the combination of low concentrations of both vitamin D and K1 provides a significant risk factor for hip fractures.

introductionThis case-cohort study aims to investigate the associations between serum vitamin K1 and hip fracture and the possible effect of 25-hydroxyvitamin D (25(OH)D) on this association.

methodsThe source cohort was 21,774 men and women aged 65 to 79 years who attended Norwegian community-based health studies during 1994-2001. Hip fractures were identified through hospital registers during median follow-up of 8.2 years. Vitamins were determined in serum obtained at baseline in all hip fracture cases (n = 1090) and in a randomly selected subcohort (n = 1318). Cox proportional hazards regression with quartiles of serum vitamin K1 as explanatory variable was performed. Analyses were further performed with the following four groups as explanatory variable: I: vitamin K1 ≥ 0.76 and 25(OH)D ≥ 50 nmol/l, II: vitamin K1 ≥ 0.76 and 25(OH)D < 50 nmol/l, III: vitamin K1 < 0.76 and 25(OH)D ≥ 50 nmol/l, and IV: vitamin K1 < 0.76 and 25(OH)D < 50 nmol/l.

resultsAge- and sex-adjusted analyses revealed an inverse association between quartiles of vitamin K1 and the risk of hip fracture. Further, a 50 % higher risk of hip fracture was observed in subjects with both low vitamin K1 and 25(OH)D compared with subjects with high vitamin K1 and 25(OH)D (HR 1.50, 95 % CI 1.18-1.90). The association remained statistically significant after adjusting for body mass index, smoking, triglycerides, and serum α-tocopherol. No increased risk was observed in the groups low in one vitamin only.

conclusionCombination of low concentrations of vitamin K1 and 25(OH)D is associated with increased risk of hip fractures.

Indexed as

AgedCohort StudiesFemaleFollow-Up StudiesHip FracturesHumansMaleNorwayRisk FactorsVitamin DVitamin D DeficiencyVitamin K 1Vitamin K Deficiency25-hydroxyvitamin DVitamin DVitamin K 1Case cohortElderlyHip fractureOsteoporosisVitamin DVitamin K1

Identifiers

PMID26630974
OpenAlexW2181985747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.