ArticlePsychoneuroendocrinology2016
Involvement of the oxytocin system in the bed nucleus of the stria terminalis in the sex-specific regulation of social recognition.
Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Sex-specific regulation of social play in juvenile rats by oxytocin neurons in the hypothalamus and oxytocin signaling in the nucleus accumbens.Hormones and behavior · 2026Article
- The Anterior BNST Is Required for Novelty-Driven Social Interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Oxytocin: a neglected hormone in pituitary disease - From function to the diagnosis of a deficiency, resulting clinical relevance, and potential treatment options in endocrinology.Archives of endocrinology and metabolism · 2025Review
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- Article
- Social anxiety disorder-associated gut microbiota increases social fear.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Prenatal allergic inflammation in rats confers sex-specific alterations to oxytocin and vasopressin innervation in social brain regions.Hormones and behavior · 2024Article
- The regulative role and mechanism of BNST in anxiety disorder.Frontiers in psychiatry · 2024Review
- Paraventricular oxytocin neurons impact energy intake and expenditure: projections to the bed nucleus of the stria terminalis reduce sucrose consumption.Frontiers in endocrinology · 2024Article
- Lasting impact of postnatal maternal separation on the developing BNST: Lifelong socioemotional consequences.Neuropharmacology · 2023Review
- Peer-induced cocaine seeking in rats: Comparison to nonsocial stimuli and role of paraventricular hypothalamic oxytocin neurons.Addiction biology · 2022Article
- The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Endogenous oxytocin, cortisol, and testosterone in response to group singing.Hormones and behavior · 2022Article
- Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71.Archives of toxicology · 2022Article
- Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances.International journal of molecular sciences · 2021Review
- Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons.Nature neuroscience · 2020Article
- Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.Handbook of behavioral neuroscience · 2020Article
- Highly structured, partner-sex- and subject-sex-dependent cortical responses during social facial touch.Nature communications · 2019Article
- Examining the contribution of histone modification to sex differences in learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sex differences in the oxytocin (OT) system in the brain may explain why OT often regulates social behaviors in sex-specific ways. However, a link between sex differences in the OT system and sex-specific regulation of social behavior has not been tested. Here, we determined whether sex differences in the OT receptor (OTR) or in OT release in the posterior bed nucleus of the stria terminalis (pBNST) mediates sex-specific regulation of social recognition in rats. We recently showed that, compared to female rats, male rats have a three-fold higher OTR binding density in the pBNST, a sexually dimorphic area implicated in the regulation of social behaviors. We now demonstrate that OTR antagonist (5 ng/0.5 μl/side) administration into the pBNST impairs social recognition in both sexes, while OT (100 pg/0.5 μl/side) administration into the pBNST prolongs the duration of social recognition in males only. These effects seem specific to social recognition, as neither treatment altered total social investigation time in either sex. Moreover, baseline OT release in the pBNST, as measured with in vivo microdialysis, did not differ between the sexes. However, males showed higher OT release in the pBNST during social recognition compared to females. These findings suggest a sex-specific role of the OT system in the pBNST in the regulation of social recognition.
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