ArticlePloS one2015
Associated Liver Partition and Portal Vein Ligation (ALPPS) vs Selective Portal Vein Ligation (PVL) for Staged Hepatectomy in a Rat Model. Similar Regenerative Response?
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Dynamic changes of pathophysiological characteristics during liver regeneration induced by associating liver partition and portal vein ligation for staged hepatectomy (ALPPS).Hepatobiliary surgery and nutrition · 2026Article
- Impact of neoadjuvant cetuximab on liver function and tumor reduction in a murine model of selective portal vein ligation.Clinical & experimental metastasis · 2025Article
- Circulating proliferative factors versus portal inflow redistribution: mechanistic insights of ALPPS-derived rapid liver regeneration.Frontiers in oncology · 2024Review
- Impact of endothelial nitric oxide synthase activation on accelerated liver regeneration in a rat ALPPS model.World journal of gastroenterology · 2023Article
- Corosolic acid inhibits tumour growth without compromising associating liver partition and portal vein ligation-induced liver regeneration in rats.Annals of medicine · 2022Article
- MMP2/9 downregulation is responsible for hepatic function recovery in cirrhotic rats following associating liver partition and portal vein ligation for staged hepatectomy.Annals of translational medicine · 2022Article
- Folinic Acid Potentiates the Liver Regeneration Process after Selective Portal Vein Ligation in Rats.Cancers · 2022Article
- Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant.Scientific reports · 2021Article
- Issues to be considered to address the future liver remnant prior to major hepatectomy.Surgery today · 2021Review
- Two-stage laparoscopic resection of giant hepatoblastoma in infants combined with liver partial partition and artery ligation.World journal of surgical oncology · 2021Article
- Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function.Frontiers in physiology · 2021Review
- The role of associating liver partition and portal vein ligation for staged hepatectomy in unresectable hepatitis B virus-related hepatocellular carcinoma.Annals of translational medicine · 2020Article
- Simulated model of RAPID concept: highlighting innate inflammation and liver regeneration.BJS open · 2020Article
- Reg3α and Reg3β Expressions Followed by JAK2/STAT3 Activation Play a Pivotal Role in the Acceleration of Liver Hypertrophy in a Rat ALPPS Model.International journal of molecular sciences · 2020Article
- RNA-Seq transcriptome profiling in three liver regeneration models in rats: comparative analysis of partial hepatectomy, ALLPS, and PVL.Scientific reports · 2020Article
- Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration.Scientific reports · 2020Article
- The Impact of Biliary Reconstruction Methods on Small Partial Liver Grafts.Transplantation direct · 2020Article
- ALPPS for hepatocarcinoma under cirrhosis: a feasible alternative to portal vein embolization.Annals of translational medicine · 2019Review
- A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis.Experimental and therapeutic medicine · 2019Article
- Associating liver partition and portal vein ligation for staged hepatectomy: establishment of an animal model with insufficient liver remnant.Laboratory investigation; a journal of technical methods and pathology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a two-stage hepatectomy technique which can be associated with a hypertrophic stimulus on the future liver remnant (FLR) stronger than other techniques--such as portal vein ligation (PVL). However, the reason of such hypertrophy is still unclear, but it is suggested that liver transection combined with portal vein ligation (ALPPS) during the first stage of this technique may play a key role. The aim of this study is to compare the hypertrophic stimulus on the FLR and the clinical changes associated with both ALPPS and PVL in a rat surgical model. For this purpose, three groups of SD rats were used, namely ALPPS (n = 30), PVL (n = 30) and sham-treated (n = 30). The second stage of ALPPS (hepatectomy of the atrophic lobes), was performed at day 8. Blood and FLR samples were collected at 1, 24, 48 hours, 8 days and 12 weeks after the surgeries. ALPPS provoked a greater degree of hypertrophy of the FLR than the PVL at 48 hours and 8 days (p<0.05). The molecular pattern was also different, with the highest expression of IL-1β at 24h, IL-6 at 8 days, and HGF and TNF-α at 48 hours and 8 days (p<0.05). ALPPS also brought about a mild proliferative stimulus at 12 weeks, with a higher expression of HGF and TGF-β (p<0.05) than PVL. Clinically, ALPPS caused a significant liver damage during the first 48 hours, with a recovery of liver function at day 8. In conclusion, ALPPS seems to induce higher functional hypertrophy on the FLR than PVL at day 8. Such regenerative response seems to be leaded by a complex interaction between pro-mitogenic (IL-6, HGF, TNF-α) and antiproliferative (IL1-β and TGF-β) cytokines.
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