ArticlePloS one2015
Impaired Hyperemic Response to Exercise Post Stroke.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Skeletal muscle changes following stroke: a systematic review and comparison to healthy individuals.Topics in stroke rehabilitation · 2017Pooled it
- Two weeks of ischemic conditioning improves walking speed and reduces neuromuscular fatigability in chronic stroke survivors.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Trial
- Stroke neurovascular responses to exercise: A novel rehabilitation paradigm.Experimental physiology · 2026Review
- Stroke Increases Neuromuscular Fatigability in Females but not Males during Isometric Exercise.Medicine and science in sports and exercise · 2026Article
- Stroke increases motor output variability during maximal voluntary isometric contractions of knee extensor muscles in adults.Physiological reports · 2026Article
- Microvascular Reactivity to Cutaneous Local Heating in the Paretic and Non-Paretic Legs of Chronic Stroke Survivors-A Pilot Study.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Motor Impairment and Disuse Are Independent Predictors of Vascular Outcomes Poststroke.Physical therapy · 2025Article
- Noninvasive estimation of skeletal muscle oxygen consumption rate and microvascular reactivity in chronic stroke survivors using near-infrared spectroscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Reduced oxygen desaturation in the vastus lateralis of chronic stroke survivors during graded muscle contractions.Topics in stroke rehabilitation · 2024Article
- Quantification of Tissue Oxygen Saturation in the Vastus Lateralis Muscle of Chronic Stroke Survivors during a Graded Exercise Test.Cardiopulmonary physical therapy journal · 2023Article
- The Facial Skin Blood Flow Change of Stroke Patients with Facial Paralysis after Peripheral Magnetic Stimulation: A Pilot Study.Brain sciences · 2022Article
- The Relationship Between Blood Flow and Motor Unit Firing Rates in Response to Fatiguing Exercise Post-stroke.Frontiers in physiology · 2019Article
- Stroke increases ischemia-related decreases in motor unit discharge rates.Journal of neurophysiology · 2018Article
- Time Course of Flow-Mediated Dilation and Vascular Endothelial Growth Factor following Acute Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals with chronic stroke have reduced perfusion of the paretic lower limb at rest; however, the hyperemic response to graded muscle contractions in this patient population has not been examined. This study quantified blood flow to the paretic and non-paretic lower limbs of subjects with chronic stroke after submaximal contractions of the knee extensor muscles and correlated those measures with limb function and activity. Ten subjects with chronic stroke and ten controls had blood flow through the superficial femoral artery quantified with ultrasonography before and immediately after 10 second contractions of the knee extensor muscles at 20, 40, 60, and 80% of the maximal voluntary contraction (MVC) of the test limb. Blood flow to the paretic and non-paretic limb of stroke subjects was significantly reduced at all load levels compared to control subjects even after normalization to lean muscle mass. Of variables measured, increased blood flow after an 80% MVC was the single best predictor of paretic limb strength, the symmetry of strength between the paretic and non-paretic limbs, coordination of the paretic limb, and physical activity. The impaired hemodynamic response to high intensity contractions was a better predictor of lower limb function than resting perfusion measures. Stroke-dependent weakness and atrophy of the paretic limb do not explain the reduced hyperemic response to muscle contraction alone as the response is similarly reduced in the non-paretic limb when compared to controls. These data may suggest a role for perfusion therapies to optimize rehabilitation post stroke.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.