ArticleObesity facts2015
Dynamics of Fat Mass in DUhTP Mice Selected for Running Performance - Fat Mobilization in a Walk.
Article in Obesity facts, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Effects of genotype and exercise on hepatic gene expression in phenotype-selected marathon mice.Scientific data · 2026Article
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- Partial phenotype conversion and differential trait response to conditions of husbandry in mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveReduction of body fat can be achieved by dietary programs and/or aerobic exercise training. More convenient methods to rid the body of excess fat are needed. However, it is unclear whether it is possible to more easily lose body weight at all.
methodsDUhTP mice bred through phenotype selection for high treadmill performance and unselected controls were voluntarily physically active in a running wheel over a period of 3 weeks. Phenotypical data were collected, and subcutaneous fat was analyzed for expression of mitochondria-relevant proteins.
resultsVoluntary physical activity over 3 weeks exclusively in DUhTP mice severely reduced subcutaneous (-38%; p < 0.05) and epididymal (-32%; p < 0.05) fat. Following mild physical activity, subcutaneous fat derived from DUhTP mice showed increased levels of long chain acyl dehydrogenase (LCAD; +230%; p < 0.05) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α; p < 0.01). Mitochondrial transcription factor A (Tfam) expression was similar in both sedentary genotypes but physical activity increased Tfam levels exclusively in DUhTP (p < 0.05).
conclusionOur findings indicate that the mitochondrial mass is highly active in DUhTP mice and responsive even to mild physical activity. While genetic predisposition could not prevent fat accretion in DUhTP mice, voluntary activity was sufficient to reduce excess body fat almost completely.
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