ArticlePLoS computational biology2015
Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Cerebellum-inspired neural network of supervised learning with tensor-based sparse coding for multi-class classification.PLoS computational biology · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Investigating health literacy and sociodemographic factors in college students.Scientific reports · 2025Article
- Electrophysiological classification ofFrontiers in pharmacology · 2025Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.eLife · 2024Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.bioRxiv : the preprint server for biology · 2023Article
- Article
- A model of on/off transitions in neurons of the deep cerebellar nuclei: deciphering the underlying ionic mechanisms.Journal of mathematical neuroscience · 2021Article
- Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling.Nature neuroscience · 2020Article
- Novel MissenseInternational journal of molecular sciences · 2020Article
- Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Biophysical Modeling Suggests Optimal Drug Combinations for Improving the Efficacy of GABA Agonists after Traumatic Brain Injuries.Journal of neurotrauma · 2019Article
- Neuronal activity and outcomes from thalamic surgery for spinocerebellar ataxia.Annals of clinical and translational neurology · 2018Article
- Area PEc Neurons Use a Multiphasic Pattern of Activity to Signal the Spatial Properties of Optic Flow.BioMed research international · 2017Article
- Article
- Modeling the Cerebellar Microcircuit: New Strategies for a Long-Standing Issue.Frontiers in cellular neuroscience · 2016Review
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3 authors.
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Abstract
Neurons of the cerebellar nuclei convey the final output of the cerebellum to their targets in various parts of the brain. Within the cerebellum their direct upstream connections originate from inhibitory Purkinje neurons. Purkinje neurons have a complex firing pattern of regular spikes interrupted by intermittent pauses of variable length. How can the cerebellar nucleus process this complex input pattern? In this modeling study, we investigate different forms of Purkinje neuron simple spike pause synchrony and its influence on candidate coding strategies in the cerebellar nuclei. That is, we investigate how different alignments of synchronous pauses in synthetic Purkinje neuron spike trains affect either time-locking or rate-changes in the downstream nuclei. We find that Purkinje neuron synchrony is mainly represented by changes in the firing rate of cerebellar nuclei neurons. Pause beginning synchronization produced a unique effect on nuclei neuron firing, while the effect of pause ending and pause overlapping synchronization could not be distinguished from each other. Pause beginning synchronization produced better time-locking of nuclear neurons for short length pauses. We also characterize the effect of pause length and spike jitter on the nuclear neuron firing. Additionally, we find that the rate of rebound responses in nuclear neurons after a synchronous pause is controlled by the firing rate of Purkinje neurons preceding it.
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