ArticlePloS one2015
Gradual Rewarming with Gradual Increase in Pressure during Machine Perfusion after Cold Static Preservation Reduces Kidney Ischemia Reperfusion Injury.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Alkaline Phosphatase Supplementation During Hypothermic and Normothermic Machine Perfusion Improves Metabolic Dysfunction in a Porcine Model of Donor Kidney Preservation.Transplantation direct · 2026Article
- A Cardioprotective perfusion protocol limits myocardial functional decline during ex situ heart perfusion.JHLT open · 2024Article
- Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys.Frontiers in immunology · 2024Article
- Loss of Endothelial Glycocalyx During Normothermic Machine Perfusion of Porcine Kidneys Irrespective of Pressure and Hematocrit.Transplantation direct · 2023Article
- HAntioxidants (Basel, Switzerland) · 2023Article
- Retrograde reperfusion of renal grafts to reduce ischemic-reperfusion injury.Korean journal of transplantation · 2022Article
- Subnormothermic Ex Vivo Porcine Kidney Perfusion Improves Energy Metabolism: Analysis UsingTransplantation direct · 2022Article
- Prolonged ex-vivo normothermic kidney perfusion: The impact of perfusate composition.PloS one · 2021Article
- Organ-specific metabolic profiles of the liver and kidney during brain death and afterwards during normothermic machine perfusion of the kidney.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Renal Procurement: Techniques for Optimizing the Quality of the Graft in the Cadaveric Setting.Current urology reports · 2020Review
- Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts DuringFrontiers in immunology · 2020Article
- Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Combined kidney‑liver perfusion enhances the proliferation effects of hypothermic perfusion on liver grafts via upregulation of IL‑6/Stat3 signaling.Molecular medicine reports · 2019Article
- [Modern concepts for the dynamic preservation of the liver and kidneys in the context of transplantation].Der Pathologe · 2019Review
- Rewarming Injury after Cold Preservation.International journal of molecular sciences · 2019Review
- Influence of Hypoxic Preservation Temperature on Endothelial Cells and Kidney Integrity.BioMed research international · 2019Article
- Article
- Role of temperature in reconditioning and evaluation of cold preserved kidney and liver grafts.Current opinion in organ transplantation · 2017Review
- Continuous Normothermic Ex Vivo Kidney Perfusion Improves Graft Function in Donation After Circulatory Death Pig Kidney Transplantation.Transplantation · 2017Article
- Article
Corrections and comments
- Erratum issuedCorrection: Gradual Rewarming with Gradual Increase in Pressure during Machine Perfusion after Cold Static Preservation Reduces Kidney Ischemia Reperfusion Injury.2016 · t Hart, Nails [corrected to \'t Hart, Nils]; Martins, Paulo [corrected to Martins, Paulo N]
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we evaluated whether gradual rewarming after the period of cold ischemia would improve organ quality in an Isolated Perfused Kidney Model. Left rat kidneys were statically cold stored in University of Wisconsin solution for 24 hours at 4°C. After cold storage kidneys were rewarmed in one of three ways: perfusion at body temperature (38°C), or rewarmed gradually from 10°C to 38°C with stabilization at 10°C for 30 min and rewarmed gradually from 10°C to 38°C with stabilization at 25°C for 30 min. In the gradual rewarming groups the pressure was increased stepwise to 40 mmHg at 10°C and 70 mmHg at 25°C to counteract for vasodilatation leading to low perfusate flows. Renal function parameters and injury biomarkers were measured in perfusate and urine samples. Increases in injury biomarkers such as aspartate transaminase and lactate dehydrogenase in the perfusate were lower in the gradual rewarming groups versus the control group. Sodium re-absorption was improved in the gradual rewarming groups and reached significance in the 25°C group after ninety minutes of perfusion. HSP-70, ICAM-1, VCAM-1 mRNA expressions were decreased in the 10°C and 25°C groups. Based on the data kidneys that underwent gradual rewarming suffered less renal parenchymal, tubular injury and showed better endothelial preservation. Renal function improved in the gradual rewarming groups versus the control group.
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