Evidence map›Paper›PMID 26629686›Full record

ReviewAnnals of the New York Academy of Sciences2016

Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis.

Wanqing Xie, Lijiang Zhou, Shan Li, Tianqian Hui, Di Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Molecular signaling in temporomandibular joint osteoarthritis.Journal of orthopaedic translation · 2022
    Review
  17. Article
  18. Article
  19. Current Status of MicroRNAs that Target the Wnt Signaling Pathway in Regulation of Osteogenesis and Bone Metabolism: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Wanqing XieDepartment of Biochemistry, Rush University Medical Center, Chicago, Illinois.
Lijiang ZhouDepartment of Biochemistry, Rush University Medical Center, Chicago, Illinois.
Shan LiDepartment of Biochemistry, Rush University Medical Center, Chicago, Illinois.
Tianqian HuiDepartment of Biochemistry, Rush University Medical Center, Chicago, Illinois.
Di ChenDepartment of Biochemistry, Rush University Medical Center, Chicago, Illinois.
Rush University Medical Center · US

Funding

The Mechanism through which TGF-Beta Maintains Chondrocytes in Proliferating StagR01AR054465 · NIAMS · UNIVERSITY OF ROCHESTER · PI CHEN, DI · 2007 to 2018
$2.7M
Pain Mechanisms of Knee Joint OsteoarthritisR01AR062136 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, DI · 2012 to 2016
$1.7M
Beta-Catenin Signaling and Pathogenesis of OsteoarthritisR01AR055915 · NIAMS · UNIVERSITY OF ROCHESTER · PI CHEN, DI · 2009 to 2013
$1.7M
Allosteric Small Molecule Inhibitor Of Nerve Growth Factor Signaling in Low Back PainR21AR067935 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, DI · 2015 to 2016
$375k
NIAMS NIH HHS AR 054465NIAMS NIH HHS AR 055915NIAMS NIH HHS R01 AR054465NIAMS NIH HHS R01 AR055915NIAMS NIH HHS R01 AR062136NIAMS NIH HHS R21 AR067935
6 · The paper itself

Abstract

Spondyloarthritis (SpA) is a group of diseases consisting of psoriatic arthritis (PsA), reactive arthritis, arthritis related to inflammatory bowel disease (a subgroup of juvenile idiopathic arthritis), and ankylosing spondylitis (the prototype of SpA). Axial bone formation and the combination of concurrent erosion and new bone formation are specific characteristics of SpA disease. The use of antiproinflammatory cytokines, such as inhibitors of tumor necrosis factor α (TNF-α), appears to be the greatest advance in the treatment of SpA over the past 20 years. However, TNF-α blockers do not halt new bone formation. Recent clinical observations and animal studies demonstrate that Wnt signaling proteins and natural Wnt inhibitors, such as DKK1 and sclerostin, are likely to play important roles in the process of ankylosis in SpA, and could potentially serve as therapeutic targets for the treatment of SpA.

Indexed as

Bone RemodelingModels, BiologicalWnt Signaling PathwayAdaptor Proteins, Signal TransducingAnimalsAnti-Inflammatory Agents, Non-SteroidalArthritis, Juvenilebeta CateninBone Morphogenetic ProteinsCartilage, ArticularGenetic MarkersHumansInflammatory Bowel DiseasesIntercellular Signaling Peptides and ProteinsMolecular Targeted TherapySpondylarthritisAdaptor Proteins, Signal TransducingAnti-Inflammatory Agents, Non-Steroidalbeta CateninBone Morphogenetic ProteinsCTNNB1 protein, humanDKK1 protein, humanGenetic MarkersIntercellular Signaling Peptides and ProteinsSOST protein, humanbone formationDKK1sclerostinspondyloarthritisWnt signaling pathwayXie, W., L. Zhou, S. Li, et al. 2015. Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis. In “MARROW,” ed. by M. Zaidi. Ann. N.Y. Acad. Sci. 1364: 25-31.

Identifiers

PMID26629686
PMCPMC4803629
OpenAlexW2188767660

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.