ArticleEBioMedicine2015
Grating-based X-ray Dark-field Computed Tomography of Living Mice.
Article in EBioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Feasibility of longitudinal in vivo monitoring of pulmonary disease progression in mouse models using laboratory-based x-ray dark-field CT.European radiology experimental · 2026Article
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- Theoretical and experimental analysis of the modulated phase grating X-ray interferometer.Scientific reports · 2024Article
- Grating-based x-ray dark-field CT for lung cancer diagnosis in mice.European radiology experimental · 2024Article
- Article
- [Dark-field imaging and computed tomography : Novel X-ray-based contrast imaging modality with great promise for pulmonary imaging].Radiologie (Heidelberg, Germany) · 2023Review
- Cycloidal-spiral sampling for three-modal x-ray CT flyscans with two-dimensional phase sensitivity.Scientific reports · 2022Article
- Dark-field tomography of an attenuating object using intrinsic x-ray speckle tracking.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Dark-field computed tomography reaches the human scale.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Retrieval of 3D information in X-ray dark-field imaging with a large field of view.Scientific reports · 2021Article
- In-vivo X-ray dark-field computed tomography for the detection of radiation-induced lung damage in mice.Physics and imaging in radiation oncology · 2021Article
- Correlation of image quality parameters with tube voltage in X-ray dark-field chest radiography: a phantom study.Scientific reports · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
- The versatile X-ray beamline of the Munich Compact Light Source: design, instrumentation and applications.Journal of synchrotron radiation · 2020Article
- The evolution of image reconstruction for CT-from filtered back projection to artificial intelligence.European radiology · 2019Review
- Quantitative morphometric analysis of adult teleost fish by X-ray computed tomography.Scientific reports · 2018Article
- [X‑ray Phase Contrast : Principles, potential and advances in clinical translation].Der Radiologe · 2018Review
- Implementation of a Talbot-Lau interferometer in a clinical-like c-arm setup: A feasibility study.Scientific reports · 2018Article
- Electron Density of Adipose Tissues Determined by Phase-Contrast Computed Tomography Provides a Measure for Mitochondrial Density and Fat Content.Frontiers in physiology · 2018Article
- Simultaneous wood and metal particle detection on dark-field radiography.European radiology experimental · 2018Article
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.