ArticleEBioMedicine2015
Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya.
Article in EBioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis.Scientific reports · 2021Pooled it
- Iron Deficiency Is Associated With Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Pooled it
- Hepcidin is low in children with moderate acute malnutrition and asymptomatic malaria: secondary analysis of a 2×2×3 factorial randomised trial in Burkina Faso.The British journal of nutrition · 2026Trial
- Trial
- Getting back on track to meet global anaemia reduction targets: a Lancet Haematology Commission.The Lancet. Haematology · 2025Review
- Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin.Nature communications · 2024Article
- Biology of Anemia: A Public Health Perspective.The Journal of nutrition · 2023Article
- Approaches to Address the Anemia Challenge.The Journal of nutrition · 2023Article
- Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study.Malaria journal · 2023Article
- Universal iron supplementation: the best strategy to tackle childhood anaemia in malaria-endemic countries?Wellcome open research · 2023Review
- Hepcidin regulation in Kenyan children with severe malaria and non-typhoidalHaematologica · 2022Article
- Malaria is a cause of iron deficiency in African children.Nature medicine · 2021Article
- Soluble transferrin receptor level, inflammation markers, malaria, alpha-thalassemia and selenium status are the major predictors of hemoglobin in children 6-23 months in Malawi.Food science & nutrition · 2020Article
- Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants.Haematologica · 2019Article
- Iron Status and Associated Malaria Risk Among African Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Observational
- The Importance of Iron Status for Young Children in Low- and Middle-Income Countries: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children.Science advances · 2019Article
- Sickle Cell and α+-Thalassemia Traits Influence the Association between Ferritin and Hepcidin in Rural Kenyan Children Aged 14-26 Months.The Journal of nutrition · 2018Article
- How Eliminating Malaria May Also Prevent Iron Deficiency in African Children.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Prevalence and Predictors of Malaria in Human Immunodeficiency Virus Infected Patients in Beira, Mozambique.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
Both iron deficiency (ID) and malaria are common among African children. Studies show that the iron-regulatory hormone hepcidin is induced by malaria, but few studies have investigated this relationship longitudinally. We measured hepcidin concentrations, markers of iron status, and antibodies to malaria antigens during two cross-sectional surveys within a cohort of 324 Kenyan children ≤ 8 years old who were under intensive surveillance for malaria and other febrile illnesses. Hepcidin concentrations were the highest in the youngest, and female infants, declined rapidly in infancy and more gradually thereafter. Asymptomatic malaria and malaria antibody titres were positively associated with hepcidin concentrations. Recent episodes of febrile malaria were associated with high hepcidin concentrations that fell over time. Hepcidin concentrations were not associated with the subsequent risk of either malaria or other febrile illnesses. Given that iron absorption is impaired by hepcidin, our data suggest that asymptomatic and febrile malaria contribute to the high burden of ID seen in African children. Further, the effectiveness of iron supplementation may be sub-optimal in the presence of asymptomatic malaria. Thus, strategies to prevent and eliminate malaria may have the added benefit of addressing an important cause of ID for African children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.