SynthesisEBioMedicine2015
Risk of All-Cause Mortality in Alcohol-Dependent Individuals: A Systematic Literature Review and Meta-Analysis.
Synthesis in EBioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05087771 (In Hospital Administration of Extended-Release Naltrexone for Alcohol Use Disorder), which is not on this map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
In Hospital Administration of Extended-Release Naltrexone for Alcohol Use Disorder: A Pilot Study of Feasibility and Acceptability
Who cites it
43 citing papers in PubMed.
- Predictors of abstinence, no heavy drinking days, and a 2-level reduction in World Health Organization drinking levels during treatment for alcohol use disorder in the COMBINE study.Alcoholism, clinical and experimental research · 2022Trial
- Effects of a minimal-guided on-line intervention for alcohol misuse in Estonia: a randomized controlled trial.Addiction (Abingdon, England) · 2022Trial
- Combined analysis of the moderating effect of a GRIK1 polymorphism on the effects of topiramate for treating alcohol use disorder.Drug and alcohol dependence · 2021Trial
- Effect of a Snack Bar Optimized to Reduce Alcohol Bioavailability: A Randomized Controlled Clinical Trial in Healthy Individuals.Journal of medicinal food · 2020Trial
- Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Trial
- Clinical Validation of Reduced Alcohol Consumption After Treatment for Alcohol Dependence Using the World Health Organization Risk Drinking Levels.Alcoholism, clinical and experimental research · 2017Trial
- High incidence of advanced liver disease and mortality in patients presenting with alcohol use disorder.Hepatology communications · 2026Article
- Improvements in Social Quality of Life for Recovering Addicts Receiving Dental Implant Rehabilitation.Cureus · 2026Article
- Comparison of mortality and causes of death between treatment-engaged individuals with severe alcohol or opioid use disorder: a prospective 19-year clinical cohort study.BMC psychiatry · 2026Observational
- Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025Article
- Alcohol and life expectancy.Environmental health and preventive medicine · 2025Article
- The prognostic impact of psychiatric intervention on alcohol-associated liver disease: The UK Biobank cohort study.Clinical and molecular hepatology · 2024Article
- Area-Level Social Determinants of Alcohol-Related Mortality: Knowledge Gaps and Implications for Community Health.Alcohol research : current reviews · 2024Review
- Impaired health-related quality of life in the HCV cure era: who is concerned? (ANRS CO22 HEPATHER French cohort).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- All-cause and cause-specific mortality in individuals with an alcohol-related emergency or hospital inpatient presentation: A retrospective data linkage cohort study.Addiction (Abingdon, England) · 2023Observational
- Prediction of chronological age and its applications in forensic casework: methods, current practices, and future perspectives.Forensic sciences research · 2023Review
- Severity of alcohol dependence and mortality after 20 years in an adult general population sample.International journal of methods in psychiatric research · 2022Article
- Mortality in adult children of parents with alcohol use disorder: a nationwide register study.European journal of epidemiology · 2022Article
- Provider perceptions of challenges to identifying women Veterans with hazardous substance use.BMC health services research · 2022Article
- Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals.Addiction biology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlcohol dependence (AD) carries a high mortality burden, which may be mitigated by reduced alcohol consumption. We conducted a systematic literature review and meta-analysis investigating the risk of all-cause mortality in alcohol-dependent subjects.
methodsMEDLINE, MEDLINE In-Process, Embase and PsycINFO were searched from database conception through 26th June 2014. Eligible studies reported all-cause mortality in both alcohol-dependent subjects and a comparator population of interest. Two individuals independently reviewed studies. Of 4540 records identified, 39 observational studies were included in meta-analyses.
findingsWe identified a significant increase in mortality for alcohol-dependent subjects compared with the general population (27 studies; relative risk [RR] = 3.45; 95% CI [2.96, 4.02]; p < 0.0001). The mortality increase was also significant compared to subjects qualifying for a diagnosis of alcohol abuse or subjects without alcohol use disorders (AUDs). Alcohol-dependent subjects continuing to drink heavily had significantly greater mortality than alcohol-dependent subjects who reduced alcohol intake, even if abstainers were excluded (p < 0.05).
interpretationAD was found to significantly increase an individual's risk of all-cause mortality. While abstinence in alcohol-dependent subjects led to greater mortality reduction than non-abstinence, this study suggests that alcohol-dependent subjects can significantly reduce their mortality risk by reducing alcohol consumption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.