Evidence map›Paper›PMID 26629421›Full record

ReviewTranslational lung cancer research2015

Treatment of advanced squamous cell carcinoma of the lung: a review.

Benjamin A Derman, Kathryn F Mileham, Philip D Bonomi, Marta Batus, Mary J Fidler

Abstract readReview
In one paragraph

Review in Translational lung cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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  15. [Licochalcone A induces cell cycle arrest in human lung squamous carcinoma cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin A Derman1 Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA ; 2 Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA ; 3 Section of Medical Oncology, Rush University Medical Center, Chicago, IL, USA.
Kathryn F Mileham1 Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA ; 2 Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA ; 3 Section of Medical Oncology, Rush University Medical Center, Chicago, IL, USA.
Philip D Bonomi1 Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA ; 2 Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA ; 3 Section of Medical Oncology, Rush University Medical Center, Chicago, IL, USA.
Marta Batus1 Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA ; 2 Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA ; 3 Section of Medical Oncology, Rush University Medical Center, Chicago, IL, USA.
Mary J Fidler1 Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA ; 2 Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA ; 3 Section of Medical Oncology, Rush University Medical Center, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer remains the single deadliest cancer both in the US and worldwide. The great majority of squamous cell carcinoma (SCC) is attributed to cigarette smoking, which fortunately is declining alongside cancer incidence. While we have been at a therapeutic plateau for advanced squamous cell lung cancer patients for several decades, recent observations suggest that we are on the verge of seeing incremental survival improvements for this relatively large group of patients. Current studies have confirmed an expanding role for immunotherapy [including programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibition], a potential opportunity for VEGFR inhibition, and even future targets in fibroblast growth factor receptor (FGFR) and PI3K-AKT that collectively should improve survival as well as quality of life for those affected by squamous cell lung cancer over the next decade.

Indexed as

angiogenesis inhibitorsepidermal growth factor receptor (EGFR)immunotherapyNon-small cell lung carcinomasquamous cell carcinoma of the lung

Identifiers

PMID26629421
PMCPMC4630512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.