Evidence map›Paper›PMID 26629414›Full record

ArticleMeta gene2015

Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma.

Gabrielle Bradshaw, Heidi G Sutherland, Emily T Camilleri, Rodney A Lea, Larisa M Haupt, Lyn R Griffiths

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Meta gene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Epigenetic Mechanisms in Type 2 Diabetes Retinopathy: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Hypermethylation in the promoter of theDiabetology & metabolic syndrome · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gabrielle BradshawGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane QLD, Australia.
Heidi G SutherlandGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane QLD, Australia.
Emily T CamilleriGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane QLD, Australia.
Rodney A LeaGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane QLD, Australia.
Larisa M HauptGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane QLD, Australia.
Lyn R GriffithsGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane QLD, Australia.
Queensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism. Polymorphisms of genes in this pathway affect its regulation and have been linked to lymphoma. In this study we examined whether we could detect an association between two common non-synonymous MTHFR polymorphisms, 677C > T (rs1801133) and 1298A > C (rs1801131), and susceptibility to non-Hodgkin lymphoma (NHL) in an Australian case-control cohort. We found no significant differences between genotype or allele frequencies for either polymorphisms between lymphoma cases and controls. We also explored whether epigenetic modification of MTHFR, specifically DNA methylation of a CpG island in the MTHFR promoter region, is associated with NHL using blood samples from patients. No difference in methylation levels was detected between the case and control samples suggesting that although hypermethylation of MTHFR has been reported in tumour tissues, particularly in the diffuse large B-cell lymphoma subtype of NHL, methylation of this MTHFR promoter CpG island is not a suitable epigenetic biomarker for NHL diagnosis or prognosis in peripheral blood samples. Further studies into epigenetic variants could focus on genes that are robustly associated with NHL susceptibility.

Indexed as

1298A > C polymorphism677C > T polymorphismBp, base pairsCGIs, CpG IslandsCIMP, CpG island methylator phenotypeDLBCL, diffuse large b-cell lymphomaDNA, deoxyribose nucleic acidDNA methylationEDTA, ethylenediaminetetra acetic acidFL, follicular lymphomaHRM, high resolution meltMTHFRMTHFR, methylenetetrahydrofolate reductaseNHL, non-Hodgkin lymphomaNon-Hodgkin lymphomaOR, odds ratioPCR, polymerase chain reactionRFLP, restriction fragment length polymorphismSD, standard deviationSNP, single nucleotide polymorphismTHF, tetrahydrofolateWHO, World Health Organisation

Identifiers

PMID26629414
PMCPMC4634355
OpenAlexW2193388484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.