Evidence map›Paper›PMID 26629169›Full record

ArticleInternational journal of clinical and experimental medicine2015

The diagnostic value of neutrophil gelatinase-associated lipocalin and hepcidin in bacteria translocation of liver cirrhosis.

Jiangguo Zhang, Fengyun Gong, Ling Li, Manzhi Zhao, Zhuhua Wu, Jianxin Song

Abstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Frontiers in microbiology · 2023
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Applied value of monitoring serum hepcidin in differential diagnosis of infection versus tumor fevers.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jiangguo ZhangDepartment of Infectious Diseases, Tongji Hospital, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China ; Department of Gastroenterology, Shekou People's Hospital Shenzhen 518052, Guangdong, P. R. China.
Fengyun GongDepartment of Infectious Diseases, The Fourth Hospital of Wuhan Wuhan 430030, Hubei, P. R. China.
Ling LiDepartment of Infectious Diseases, Tongji Hospital, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China.
Manzhi ZhaoDepartment of Infectious Diseases, Tongji Hospital, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China.
Zhuhua WuDepartment of Infectious Diseases, Tongji Hospital, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China.
Jianxin SongDepartment of Infectious Diseases, Tongji Hospital, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China.
Huazhong University of Science and Technology Hospital · CNHuazhong University of Science and Technology · CNWuhan Puai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBacterial translocation (BT) or bacterial DNA (bactDNA) translocation is a critical pathogenesis mechanism of spontaneous bacterial peritonitis. Studies of BT or bactDNA translocation are limited in humans. Neutrophil gelatinase associated lipocalin (NGAL) can efficiently distinguish bacterial and nonbacterial ascites in ascitic patients. Hepcidin is a useful marker of bacterial infection in the late-onset sepsis. However, the relationship between NGAL, hepcidin and BT was still unclear. In present study, the levels of NGAL, hepcidin and their relationship with BT or bactDNA translocation were investigated. MATERIAL AND

methodsWeekly doses of carbon tetrachloride (CCl4) were given to induce liver cirrhosis in Sprague-Dawley rats. Trypticase (blood) soy agars were used to culture bacteria. BactDNA was sequenced by ABIPRISM 310 automated sequencer. The levels of NGAL and hepcidin were assessed by ELISA. Receiver operating characteristic (ROC) curve was used to determine the cut-off values and compare the diagnostic performance of NGAL and hepcidin.

results56 cirrhotic and 10 normal rats were included in this study. The levels of both two biomarkers were significantly higher in BT or bactDNA translocation group compared to non-translocation group. The area under ROC curve for the diagnosis of BT was 0.910 for serum NGAL, 0.858 for serum hepcidin and 0.940 for their combination, whereas that for the diagnosis of bactDNA translocation was 0.906 for NGAL, 0.779 for hepcidin and 0.950 for their combination, respectively. The combination of NGAL and hepcidin improved the ability to detect BT or bactDNA presence in MLNs and ascites.

conclusionBT and the presence of bactDNA in MLNs were observed in a rat cirrhotic model. Serum NGAL and hepcidin can serve as sensitive and specific tests for diagnosis of BT or bactDNA translocation. NGAL in combination with hepcidin can improve the accuracy of diagnosis.

Indexed as

bacterial DNA translocationBacterial translocationhepcidinliver cirrhosisneutrophil gelatinase associated lipocalinROC curve

Identifiers

PMID26629169
PMCPMC4659057
OpenAlexW2247551811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.